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Oligoclonal bands in multiple sclerosis patients: worse prognosis?
MedLine Citation:
PMID:  22909670     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Cerebrospinal fluid (CSF) oligoclonal bands (OB) imply intrathecal immunoglobulin synthesis and B-cell immune process. There is scarce evidence of OB having a role in disease prognosis. The objective of the present study was to determine OB?s prognostic value regarding disease progression. METHODS: Between January 1994 and January 2007, relapsing-remitting MS (RRMS) patients in which OB were determined were included. Demographic, clinical aspects and presence of OB were analyzed. We compared OB+ versus OB- patients regarding progression to expanded disability status scale (EDSS) of 6.0 and to secondary progressive MS (SPMS). Cox proportional hazard models were used to compare the outcome between groups. P values <0.05 were considered significant. RESULTS: One hundred and ninety-six patients were included. In 176 patients (90%), the CSF showed type II OB, 20 (10%) patients were OB negative. There were no differences between age, clinical presentation and EDSS at onset or in the immunomodulatory treatment received between OB+ and OB- patients. Sixty-two (31.6%) patients converted to SPMS during the follow-up, 59 (33.5%) were OB+ and 3 (15%) were OB-. EDSS of 6 was recorded in 56 (28.5%) patients during the follow-up; 54 (31%) were OB+ while only 2 (10%) OB- patients reached this outcome (reach SP phase, P=0.032; HR: 2.2; 95% CI: 1.3?7.5 and EDSS of 6, P=0.037; HR: 1.9; 95% CI: 1.3?8.5). CONCLUSION: We observed during the follow-up that OB- patients had a better prognosis and milder disability compared to OB+ patients.
Authors:
J I Rojas; S Tizio; L Patrucco; E Cristiano
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-20
Journal Detail:
Title:  Neurological research     Volume:  -     ISSN:  1743-1328     ISO Abbreviation:  Neurol. Res.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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