| Oligoclonal bands in cerebrospinal fluid in patients with Tourette's syndrome. | |
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MedLine Citation:
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PMID: 20960488 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Since a postinfectious or autoimmune etiology is suggested to be involved in the pathogenesis of Tourette's syndrome (TS), we investigated oligoclonal bands (OB) of immunoglobulin G (IgG) in cerebrospinal fluid (CSF), indicating a humoral immune response in the central nervous system. CSF examinations including isoelectric focusing to analyze the presence of OB were performed in 21 TS patients [17 men/4 women, mean age = 29 ± 12 (SD) years]. Isoelectric focusing showed the presence of positive OB in 6, borderline bands in 2, and serum and CSF bands ("mirrored pattern") in another 2 patients. Clinical data did not correlate with CSF findings. Thus, 38% (8 of 21) of our patients exhibited pathological CSF bands. Since none of them suffered from another disease known to be associated with OB, our results suggest an association with the pathogenesis of TS itself and point to an involvement of immunological mechanisms in TS pathology. © 2010 Movement Disorder Society. |
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Authors:
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Claudia Wenzel; Ulrich Wurster; Kirsten R Müller-Vahl |
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Publication Detail:
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Type: Journal Article Date: 2010-10-19 |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 26 ISSN: 1531-8257 ISO Abbreviation: Mov. Disord. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 343-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Movement Disorder Society. |
Affiliation:
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Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany. Wenzel.Claudia@MH-Hannover.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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