Document Detail


Olfactory neuroblastoma. Response to combination chemotherapy.
MedLine Citation:
PMID:  7362526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A patient with olfactory neuroblastoma who had bone marrow metastasis at the time of diagnosis is presented. Previous therapy for this disease consisted of surgery and radiation. There is limited information relating to the efficacy of chemotherapy. Our patient was treated with combination chemotherapy (dacarbazine [DTIC-Dome], cyclophosphamide [Cytoxan], doxorubicin hydrochloride [Adriamycin], and vincristine sulfate [Oncovin]) and radiation to the primary site. Objective findings, more than two years after diagnosis, support a good partial response. Although a 50%, five-year survival time has been reported, the five-year cure rate is 18%. This report suggests that the role of combination chemotherapy should be further evaluated in certain patients with olfactory neuroblastoma.
Authors:
T R Walters; N Pushparaj; A Z Ghander
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of otolaryngology (Chicago, Ill. : 1960)     Volume:  106     ISSN:  0003-9977     ISO Abbreviation:  Arch Otolaryngol     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376526     Medline TA:  Arch Otolaryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  242-3     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Agents / therapeutic use
Bone Marrow Diseases / complications
Female
Hearing Loss, Conductive / complications
Humans
Maxillary Sinus / surgery*
Neoplasm Metastasis
Neuroectodermal Tumors, Primitive, Peripheral / drug therapy,  surgery*
Nose Neoplasms / drug therapy,  surgery*
Paranasal Sinus Neoplasms / surgery*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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