| Olfactory influences on mood and autonomic, endocrine, and immune function. | |
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MedLine Citation:
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PMID: 18178322 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite aromatherapy's popularity, efficacy data are scant, and potential mechanisms are controversial. This randomized controlled trial examined the psychological, autonomic, endocrine, and immune consequences of one purported relaxant odor (lavender), one stimulant odor (lemon), and a no-odor control (water), before and after a stressor (cold pressor); 56 healthy men and women were exposed to each of the odors during three separate visits. To assess the effects of expectancies, participants randomized to the "blind" condition were given no information about the odors they would smell; "primed" individuals were told what odors they would smell during the session, and what changes to expect. Experimenters were blind. Self-report and unobtrusive mood measures provided robust evidence that lemon oil reliably enhances positive mood compared to water and lavender regardless of expectancies or previous use of aromatherapy. Moreover, norepinephrine levels following the cold pressor remained elevated when subjects smelled lemon, compared to water or lavender. DTH responses to Candida were larger following inhalation of water than lemon or lavender. Odors did not reliably alter IL-6 and IL-10 production, salivary cortisol, heart rate or blood pressure, skin barrier repair following tape stripping, or pain ratings following the cold pressor. |
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Authors:
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Janice K Kiecolt-Glaser; Jennifer E Graham; William B Malarkey; Kyle Porter; Stanley Lemeshow; Ronald Glaser |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Psychoneuroendocrinology Volume: 33 ISSN: 0306-4530 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-02-22 Completed Date: 2008-05-13 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: England |
Other Details:
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Languages: eng Pagination: 328-39 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, The Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA. Kiecolt-Glaser.1@osu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Affect / physiology* Autonomic Nervous System / physiology* Candida / immunology Cold Temperature / diagnostic use Cues Endocrine Glands / physiology* Female Health Behavior Humans Hypersensitivity, Delayed / immunology Immunity / physiology* Male Oils, Volatile / pharmacology Pentanols / diagnostic use Phenylethyl Alcohol / diagnostic use Pressure Psychological Tests Set (Psychology) Sex Characteristics Smell / physiology* Stimulation, Chemical |
| Grant Support | |
ID/Acronym/Agency:
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AI55411/AI/NIAID NIH HHS; AT002122/AT/NCCAM NIH HHS; CA16058/CA/NCI NIH HHS; M01 RR000034-440675/RR/NCRR NIH HHS; M01 RR000034-450686/RR/NCRR NIH HHS; M01 RR000034-460686/RR/NCRR NIH HHS; M01-RR-0034/RR/NCRR NIH HHS; R21 AT002122-01/AT/NCCAM NIH HHS; R21 AT002122-02/AT/NCCAM NIH HHS; T32 AI055411-05/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Oils, Volatile; 0/Pentanols; 60-12-8/Phenylethyl Alcohol; 628-63-7/amyl acetate |
| Comments/Corrections | |
Comment In:
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Psychoneuroendocrinology. 2008 Oct;33(9):1302-3; author reply 1303
[PMID:
18692320
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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