Document Detail


Olfactory impairments in patients with unilateral cerebellar lesions are selective to inputs from the contralesional nostril.
MedLine Citation:
PMID:  16000626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Functional imaging studies of olfaction have consistently reported odorant-induced activation of the cerebellum. However, the cerebellar role in olfaction remains unknown. We examined the olfactory and olfactomotor abilities of patients with unilateral cerebellar lesions, comparing performance within subjects across nostrils, as well as between subjects with age-matched and young controls. Regarding olfactory performance, initial testing revealed that patients had a contralesional impairment in olfactory identification but not olfactory detection threshold. However, when tested under conditions that prevented compensatory sniffing strategies, the patients also exhibited a contralesional olfactory detection impairment. Regarding olfactomotor function, a healthy olfactomotor system generates sniffs that are (1) sufficiently vigorous and (2) inversely proportional to odorant concentration in sniff mean airflow velocity, maximum airflow velocity, volume, and duration. Patients' sniffs were lower in overall airflow velocity and volume in comparison with control participants. Furthermore, reduced sniff velocity predicted poorer detection thresholds in patients. Finally, whereas young controls used concentration-dependent sniffs, there was a trend in that direction only for age-matched controls. Patients used sniffs that were concentration invariant. In conclusion, cerebellar lesions impacted olfactory and olfactomotor performance. These findings strongly implicate an olfactocerebellar pathway prominent in odor identification and detection that functionally connects each nostril primarily to the contralateral cerebellum.
Authors:
Joel D Mainland; Bradley N Johnson; Rehan Khan; Richard B Ivry; Noam Sobel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  25     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-07     Completed Date:  2006-02-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6362-71     Citation Subset:  IM    
Affiliation:
Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, California 94720, USA. mainland@uclink.berkeley.edu
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Adult
Age Factors
Aged
Agnosia / physiopathology*
Case-Control Studies
Cerebellar Neoplasms / complications,  pathology,  surgery
Cerebellum / injuries*,  pathology
Dominance, Cerebral*
Dose-Response Relationship, Drug
Humans
Inhalation / physiology*
Likelihood Functions
Magnetic Resonance Imaging
Male
Middle Aged
Nasal Cavity / physiopathology*
Odors*
Olfaction Disorders / etiology,  physiopathology*
Olfactory Pathways / physiopathology*
Pulmonary Ventilation / physiology*
Sensory Thresholds
Smoking
Stroke / complications,  pathology
Grant Support
ID/Acronym/Agency:
NS 30256/NS/NINDS NIH HHS; NS 40813/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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