Document Detail

Olfactory and gustatory function in irritable bowel syndrome.
MedLine Citation:
PMID:  20041259     Owner:  NLM     Status:  MEDLINE    
Irritable bowel syndrome (IBS) is the most common, functional disorder diagnosed by gastroenterologists. It is still unclear whether IBS has a central etiology, e.g., hyperreactivity of the brain, or a peripheral etiology, e.g., stimulation of olfactory/gustatory receptors on enterochromaffin cells, followed by serotonin release and changed gut motility. Testing the odor identification (ID), odor discrimination (DIS) and odor threshold (THR) as well as the total taste and the taste qualities "sweet", "sour", "salty" and "bitter" should be of help for determining the etiology. To our knowledge, this is the first study investigating the olfactory/gustatory function in IBS patients. The olfactory/gustatory function of 43 patients (32 women, 11 men) suffering from IBS as defined by the ROME III criteria was investigated by means of validated tests (Sniffin' Sticks and taste strips). Compared to normative data, scores of THR were decreased and scores of ID and DIS were increased in IBS patients. Additionally, when compared to normative data, there was no difference in the taste function of IBS patients. Assuming that THR reflects more the peripheral olfactory function, whereas ID and DIS are influenced by central activity, and that taste did not differ in IBS patients compared to normative data, this supports the idea of a central etiology of IBS.
Silke Steinbach; Wolfgang Reindl; Claudia Kessel; Roland Ott; Thomas Zahnert; Walter Hundt; Petra Heinrich; Dieter Saur; Wolfgang Huber
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Publication Detail:
Type:  Journal Article     Date:  2009-12-30
Journal Detail:
Title:  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery     Volume:  267     ISSN:  1434-4726     ISO Abbreviation:  Eur Arch Otorhinolaryngol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002937     Medline TA:  Eur Arch Otorhinolaryngol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1081-7     Citation Subset:  IM    
Department of Otorhinolaryngology, Philipps University, Deutschhausstrasse 3, 35037 Marburg, Germany.
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MeSH Terms
Chi-Square Distribution
Irritable Bowel Syndrome / complications*,  physiopathology
Middle Aged
Olfaction Disorders / etiology*,  physiopathology
Statistics, Nonparametric
Taste Disorders / etiology*,  physiopathology

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