Document Detail


Olfactory function in acute rhinitis.
MedLine Citation:
PMID:  9929658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was performed to investigate the effects of the common cold on olfactory function, which was assessed using chemosensory event-related potentials (CSERP, in response to both olfactory [H2S] and trigeminal [CO2] stimuli) and psychophysical measures (intensity ratings, odor discrimination, butanol threshold); nasal volume was assessed by means of acoustic rhinometry. The investigation was performed in 36 subjects (18 women, 18 men). After onset of the rhinitis (day 0) measurements were performed on days 2, 4, 6 and 35. The cold produced a decrease of the volume of the anterior nasal cavity accompanied by an increase of mucus secretion, an increase of olfactory thresholds, a decrease of intensity ratings and a decrease of N1 CSERP amplitudes to olfactory and trigeminal stimuli. When mucus secretion of the contralateral nasal cavity was controlled with oxymetazoline, N1 amplitudes to olfactory stimuli were still affected by the cold as indicated by the significant increase of amplitudes as subjects recovered; this phenomenenon was not found for responses to trigeminal stimuli. This indicates that the common cold has a small effect on olfactory function which may be independent of nasal congestion.
Authors:
T Hummel; C Rothbauer; S Barz; K Grosser; E Pauli; G Kobal
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  855     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-24     Completed Date:  1999-02-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  616-24     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology, University of Dresden, Germany. hummeltc@compuserve.com
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Double-Blind Method
Female
Humans
Male
Odors
Olfactory Bulb / physiology
Rhinitis / physiopathology*,  psychology
Smell / physiology*
Trigeminal Nuclei / physiology
Grant Support
ID/Acronym/Agency:
P01 DC 00161/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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