Document Detail


Olfactory ensheathing glia and Schwann cells exhibit a distinct interaction behavior with meningeal cells.
MedLine Citation:
PMID:  19140223     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Schwann cells (SCs) and olfactory ensheathing glia (OEG) have both been used as cellular transplants to promote spinal cord repair. Both cell types support axonal regeneration and have beneficial effects on functional recovery. A significant difference between SCs and OEG is the effect of these cell types on astrocytes (ACs) present in the neural scar. In contrast to OEG, which associate and intermingle with ACs, SCs and ACs form separate cellular territories. Here, we show that OEG and SCs also interact differently with meningeal cells (MCs), another major cellular component of the neural scar. Whereas OEG intermingle with MCs in cocultures, SCs aggregate into well-defined cell clusters. Our data suggest that (a) soluble factor(s) as well as direct cellular contact are involved in the MC-induced SC clustering. Furthermore, the cluster formation of SCs in coculture with MCs is different from the previously reported segregation of SCs and ACs in coculture. The present results help to understand the differential behavior of both cell types after transplantation in the injured spinal cord and will be important to either determine which cell has optimal capacities to render the scar more permissive for regeneration, or to exploit the transplantation of both cell types in combination.
Authors:
Elske H P Franssen; Kasper C D Roet; Freddy M de Bree; Joost Verhaagen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  87     ISSN:  1097-4547     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-09     Completed Date:  2009-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1556-64     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Wiley-Liss, Inc.
Affiliation:
Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / physiology
Cell Aggregation / physiology
Coculture Techniques
Culture Media, Conditioned
Female
Immunohistochemistry
Meninges / cytology,  physiology*,  secretion
Neuroglia / physiology*
Olfactory Bulb / physiology
Rats
Rats, Inbred F344
Schwann Cells / physiology*
Sciatic Nerve / physiology
Chemical
Reg. No./Substance:
0/Culture Media, Conditioned

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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