Document Detail

Olfactory dysfunction in hereditary ataxia and basal ganglia disorders.
MedLine Citation:
PMID:  12876469     Owner:  NLM     Status:  MEDLINE    
In the present study the olfactory system of hereditary ataxia patients was tested using the smell identification test. Two previous findings suggested a possible olfactory impairment in these patients. First, an olfactory dysfunction has been found in different neurodegenerative diseases, and second, human functional imaging has shown cerebellar activation during olfaction. As an initial approach to determine if cerebellar ataxia impairs the olfactory process, cerebellar ataxia patients, along with basal ganglia patients, were tested. The results show an olfactory deficit in both basal ganglia and hereditary ataxia patients. Further exploration of the olfactory capacities in hereditary ataxia is necessary to elucidate the specific nature of the deficits.
Juan Fernandez-Ruiz; Rosalinda Díaz; Cynthia Hall-Haro; Patricia Vergara; Aldo Fiorentini; Lilia Nuñez; René Drucker-Colín; Adriana Ochoa; Petra Yescas; Astrid Rasmussen; Maria-Elisa Alonso
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  14     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-23     Completed Date:  2003-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  1339-41     Citation Subset:  IM    
Depto. Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., AP 70-250.
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MeSH Terms
Basal Ganglia Diseases / complications*,  physiopathology*
Middle Aged
Neuropsychological Tests
Olfaction Disorders / etiology*
Psychiatric Status Rating Scales
Smell / physiology
Spinocerebellar Degenerations / complications*,  physiopathology*

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