Document Detail

Olfactory dysfunction and cardiovascular dysautonomia in Parkinson's disease.
MedLine Citation:
PMID:  20119648     Owner:  NLM     Status:  MEDLINE    
Several studies have reported that olfactory dysfunction is an early neuropathological manifestation of Parkinson's disease (PD). Reduced cardiac meta-iodobenzylguanidine ((123)I-MIBG) uptake may be one of the earliest signs of PD. We studied the relation of olfactory dysfunction to cardiovascular dysautonomia in patients with PD. The study group comprised 66 patients with PD (70.5 years) and 26 controls (70.3 years) for olfactory assessment, 21 controls (72.1 years) for cardiac (123)I-MIBG scintigraphy and heart rate variability (HRV), assessed using the coefficient of variation for RR intervals (HRV), and 23 controls (69.2 years) for orthostatic blood pressure response. Olfactory function was assessed by the odor stick identification test Japan (OSIT-J), and cardiovascular autonomic function was evaluated by (123)I-MIBG scintigraphy of the heart, the fall in orthostatic blood pressure, and HRV. Patients with PD had a significantly lower OSIT-J score than did the controls (4.1 +/- 3.0 vs. 9.9 +/- 1.7, p = 0.001). The OSIT-J score was unrelated to variables other than gender, including age, disease duration, motor score on the unified Parkinson's disease rating scale, score on the mini-mental state examination, motor phenotype, visual hallucinations, and dopaminergic medication on multiple regression and logistic regression analyses. The OSIT-J score was related to the heart/mediastinum ratio of cardiac (123)I-MIBG uptake, the fall in orthostatic blood pressure, and HRV, after adjustment for other clinical variables. Olfactory dysfunction in PD was, thus, significantly related to both cardiac sympathetic and parasympathetic dysfunction, as well as vascular sympathetic dysfunction. As non-motor symptoms of PD, olfactory dysfunction and autonomic network failure appear to be closely related in PD.
Hisayoshi Oka; Chizuko Toyoda; Makiko Yogo; Soichiro Mochio
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Publication Detail:
Type:  Journal Article     Date:  2010-01-30
Journal Detail:
Title:  Journal of neurology     Volume:  257     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  969-76     Citation Subset:  IM    
Department of Neurology, Daisan Hospital, The University School of Medicine, 4-11-1, Izumihoncho, Komae, Tokyo 201-8601, Japan.
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MeSH Terms
Aged, 80 and over
Blood Pressure
Cardiovascular Diseases / complications*,  physiopathology,  radionuclide imaging
Case-Control Studies
Heart / radionuclide imaging
Heart Rate
Middle Aged
Olfaction Disorders / complications*,  physiopathology
Parkinson Disease / complications*,  physiopathology,  radionuclide imaging
Pattern Recognition, Physiological
Physical Stimulation
Primary Dysautonomias / complications*,  physiopathology,  radionuclide imaging
Radionuclide Imaging
Severity of Illness Index
Sex Factors
Reg. No./Substance:

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