Document Detail


Olfactory bulbectomy counteracts inhibitory effect of food restriction on reproductive function.
MedLine Citation:
PMID:  8024044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have shown that bilateral removal of the olfactory bulbs (BX) results in a large increase in gonadotropin secretion in golden hamsters. The principal question addressed by the present study was whether BX would offset the inhibitory effect of food restriction on reproductive function. BX or sham (SH) BX male golden hamsters were fed ad libitum or were restricted to only enough food to maintain them at 70% of the body weight of control groups fed ad libitum. The SH-70% group underwent marked testicular regression after approximately 6-8 wk, but the testes size of the BX-70% hamsters decreased only in proportion to the decrease in body weight. The BX food-restricted group had to be fed more food to maintain the same weight as the SH-70% hamsters, and the BX-70% group also had a higher core body temperature, lower percent body fat, and higher serum free thyroxine levels than SH food-restricted animals. In summary, removal of the olfactory bulbs appears to facilitate tonic gonadotropin secretion, such that food restriction is no longer capable of inducing testicular regression. In addition, the olfactory bulbs may have a strong influence on metabolic function in golden hamsters.
Authors:
D R Pieper; C A Lobocki; K H Karo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  266     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-08-02     Completed Date:  1994-08-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1891-5     Citation Subset:  IM    
Affiliation:
Department of Physiology, Providence Hospital, Southfield, Michigan 48037.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / anatomy & histology
Animals
Body Temperature
Body Weight
Cricetinae
Eating
Food Deprivation / physiology*
Gonadal Steroid Hormones / blood
Male
Motor Activity / physiology
Olfactory Bulb / physiology*
Organ Size
Reproduction*
Testis / anatomy & histology
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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