Document Detail

Olfactory ferric and ferrous iron absorption in iron-deficient rats.
MedLine Citation:
PMID:  22492739     Owner:  NLM     Status:  MEDLINE    
The absorption of metals from the nasal cavity to the blood and the brain initiates an important route of occupational exposures leading to health risks. Divalent metal transporter-1 (DMT1) plays a significant role in the absorption of intranasally instilled manganese, but whether iron uptake would be mediated by the same pathway is unknown. In iron-deficient rats, blood (59)Fe levels after intranasal administration of the radioisotope in the ferrous form were significantly higher than those observed for iron-sufficient control rats. Similar results were obtained when ferric iron was instilled intranasally, and blood levels of (59)Fe were even greater in the iron-deficient rats compared with the amount of ferrous iron absorbed. Experiments with Belgrade (b/b) rats showed that DMT1 deficiency limited ferric iron uptake from the nasal cavity to the blood compared with +/b controls matched for iron deficiency. These results indicate that olfactory uptake of ferric iron by iron-deficient rats involves DMT1. Western blot experiments confirmed that DMT1 levels are significantly higher in iron-deficient rats compared with iron-sufficient controls in olfactory tissue. Thus the molecular mechanism of olfactory iron absorption is regulated by body iron status and involves DMT1.
V M Ruvin Kumara; Marianne Wessling-Resnick
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-06
Journal Detail:
Title:  American journal of physiology. Lung cellular and molecular physiology     Volume:  302     ISSN:  1522-1504     ISO Abbreviation:  Am. J. Physiol. Lung Cell Mol. Physiol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-18     Completed Date:  2012-08-23     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100901229     Medline TA:  Am J Physiol Lung Cell Mol Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  L1280-6     Citation Subset:  IM    
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
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MeSH Terms
Administration, Intranasal
Anemia, Iron-Deficiency / metabolism*
Cation Transport Proteins / deficiency,  genetics,  metabolism*
Ferric Compounds / administration & dosage,  pharmacokinetics*
Ferrous Compounds / administration & dosage,  pharmacokinetics*
Ion Transport
Iron / blood*
Iron Radioisotopes
Nasal Mucosa / metabolism*
Rats, Sprague-Dawley
Tissue Distribution
Grant Support
Reg. No./Substance:
0/Cation Transport Proteins; 0/Ferric Compounds; 0/Ferrous Compounds; 0/Iron Radioisotopes; 0/solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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