Document Detail


Olfactory ferric and ferrous iron absorption in iron-deficient rats.
MedLine Citation:
PMID:  22492739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The absorption of metals from the nasal cavity to the blood and the brain initiates an important route of occupational exposures leading to health risks. Divalent metal transporter-1 (DMT1) plays a significant role in the absorption of intranasally instilled manganese, but whether iron uptake would be mediated by the same pathway is unknown. In iron-deficient rats, blood (59)Fe levels after intranasal administration of the radioisotope in the ferrous form were significantly higher than those observed for iron-sufficient control rats. Similar results were obtained when ferric iron was instilled intranasally, and blood levels of (59)Fe were even greater in the iron-deficient rats compared with the amount of ferrous iron absorbed. Experiments with Belgrade (b/b) rats showed that DMT1 deficiency limited ferric iron uptake from the nasal cavity to the blood compared with +/b controls matched for iron deficiency. These results indicate that olfactory uptake of ferric iron by iron-deficient rats involves DMT1. Western blot experiments confirmed that DMT1 levels are significantly higher in iron-deficient rats compared with iron-sufficient controls in olfactory tissue. Thus the molecular mechanism of olfactory iron absorption is regulated by body iron status and involves DMT1.
Authors:
V M Ruvin Kumara; Marianne Wessling-Resnick
Related Documents :
8444319 - Non-transferrin-bound-iron in serum and low-molecular-weight-iron in the liver of dieta...
11140169 - Effect of dietary copper and iron restriction on aconitase activity and antioxidant cap...
1750569 - Development of passive permeability characteristics of rat placenta during the last thi...
3236899 - Lymph node siderosis in trypan blue treated rats.
6026669 - Carbon-14 and tritium measurement by means of bremsstrahlung emissions.
12720269 - Comparison between signal-to-noise ratio, liver-to-muscle ratio, and 1/t2 for the nonin...
2279909 - Lipid-coated ultrastable microbubbles as a contrast agent in neurosonography.
17972119 - On the border: perimeter patrolling as a transitional exploratory phase in a diurnal ro...
7630039 - A supplemental measure of stay-times in the light box on step-through passive avoidance.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-06
Journal Detail:
Title:  American journal of physiology. Lung cellular and molecular physiology     Volume:  302     ISSN:  1522-1504     ISO Abbreviation:  Am. J. Physiol. Lung Cell Mol. Physiol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-18     Completed Date:  2012-08-23     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100901229     Medline TA:  Am J Physiol Lung Cell Mol Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  L1280-6     Citation Subset:  IM    
Affiliation:
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorption
Administration, Intranasal
Anemia, Iron-Deficiency / metabolism*
Animals
Cation Transport Proteins / deficiency,  genetics,  metabolism*
Female
Ferric Compounds / administration & dosage,  pharmacokinetics*
Ferrous Compounds / administration & dosage,  pharmacokinetics*
Ion Transport
Iron / blood*
Iron Radioisotopes
Male
Nasal Mucosa / metabolism*
Rats
Rats, Sprague-Dawley
Tissue Distribution
Grant Support
ID/Acronym/Agency:
R01-ES014638/ES/NIEHS NIH HHS; R01-ES014638-05S1/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Cation Transport Proteins; 0/Ferric Compounds; 0/Ferrous Compounds; 0/Iron Radioisotopes; 0/solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2; 7439-89-6/Iron
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Doctors in Ancient Greek and Roman Rhetorical Education.
Next Document:  The CFTR and ENaC debate: how important is ENaC in CF lung disease?