| Olfactory ferric and ferrous iron absorption in iron-deficient rats. | |
| | |
MedLine Citation:
|
PMID: 22492739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The absorption of metals from the nasal cavity to the blood and the brain initiates an important route of occupational exposures leading to health risks. Divalent metal transporter-1 (DMT1) plays a significant role in the absorption of intranasally instilled manganese, but whether iron uptake would be mediated by the same pathway is unknown. In iron-deficient rats, blood (59)Fe levels after intranasal administration of the radioisotope in the ferrous form were significantly higher than those observed for iron-sufficient control rats. Similar results were obtained when ferric iron was instilled intranasally, and blood levels of (59)Fe were even greater in the iron-deficient rats compared with the amount of ferrous iron absorbed. Experiments with Belgrade (b/b) rats showed that DMT1 deficiency limited ferric iron uptake from the nasal cavity to the blood compared with +/b controls matched for iron deficiency. These results indicate that olfactory uptake of ferric iron by iron-deficient rats involves DMT1. Western blot experiments confirmed that DMT1 levels are significantly higher in iron-deficient rats compared with iron-sufficient controls in olfactory tissue. Thus the molecular mechanism of olfactory iron absorption is regulated by body iron status and involves DMT1. |
| | |
Authors:
|
V M Ruvin Kumara; Marianne Wessling-Resnick |
Related Documents
:
|
8444319 - Non-transferrin-bound-iron in serum and low-molecular-weight-iron in the liver of dieta... 11140169 - Effect of dietary copper and iron restriction on aconitase activity and antioxidant cap... 1750569 - Development of passive permeability characteristics of rat placenta during the last thi... 3236899 - Lymph node siderosis in trypan blue treated rats. 6026669 - Carbon-14 and tritium measurement by means of bremsstrahlung emissions. 12720269 - Comparison between signal-to-noise ratio, liver-to-muscle ratio, and 1/t2 for the nonin... 2279909 - Lipid-coated ultrastable microbubbles as a contrast agent in neurosonography. 17972119 - On the border: perimeter patrolling as a transitional exploratory phase in a diurnal ro... 7630039 - A supplemental measure of stay-times in the light box on step-through passive avoidance. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-04-06 |
Journal Detail:
|
Title: American journal of physiology. Lung cellular and molecular physiology Volume: 302 ISSN: 1522-1504 ISO Abbreviation: Am. J. Physiol. Lung Cell Mol. Physiol. Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-06-18 Completed Date: 2012-08-23 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 100901229 Medline TA: Am J Physiol Lung Cell Mol Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: L1280-6 Citation Subset: IM |
Affiliation:
|
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorption Administration, Intranasal Anemia, Iron-Deficiency / metabolism* Animals Cation Transport Proteins / deficiency, genetics, metabolism* Female Ferric Compounds / administration & dosage, pharmacokinetics* Ferrous Compounds / administration & dosage, pharmacokinetics* Ion Transport Iron / blood* Iron Radioisotopes Male Nasal Mucosa / metabolism* Rats Rats, Sprague-Dawley Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
|
R01-ES014638/ES/NIEHS NIH HHS; R01-ES014638-05S1/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cation Transport Proteins; 0/Ferric Compounds; 0/Ferrous Compounds; 0/Iron Radioisotopes; 0/solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Doctors in Ancient Greek and Roman Rhetorical Education.
Next Document: The CFTR and ENaC debate: how important is ENaC in CF lung disease?