Document Detail


Olfactory bulbectomy impairs the feeding response to 2-deoxy-D-glucose in rats.
MedLine Citation:
PMID:  20969838     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
An early study reported that, unlike sham-operated rats, rats made anosmic by olfactory bulbectomy (OBX) failed to compensate for the dilution of their diet with nonnutritive bulk by increasing their food intake. In the present study, the effects of a glucoprivic challenge, intraperitoneal-administered 350 mg/kg 2-deoxy-D-glucose (2-DG), on food intake were measured in OBX and sham-operated female rats. Sham-operated rats significantly increased their food intake, but in two separate experiments OBX rats displayed no increase in food intake during the first 2 h following administration. Blood glucose levels were nearly identical in both groups. Body weights and daily food intakes of OBX rats did not differ from the sham-operated controls throughout the studies. Bulbectomized rats also displayed a normal drinking response after an intraperitoneal injection of 1M hypertonic saline. Hypothalamic nuclei and the neural pathways mediating taste have been implicated in the feeding response to 2-DG. The present results suggest that olfactory input and olfactory neural pathways also mediate, at least in part, the feeding response to a glucoprivic challenge induced by intraperitoneal injection of 2-DG.
Authors:
Bruce M King; Stefany D Primeaux; Mohammad L Zadeh; John E de Gruiter; Joshua D Plant; Adam V Ferguson; George A Bray
Related Documents :
6575038 - Rat caries assay of reference foods and sugar-containing snacks.
19043208 - Fluvoxamine inhibits weight gain and food intake in food restricted hyperphagic wistar ...
1654568 - Role of diurnal variation and receptor specificity in the opioidergic regulation of foo...
2029348 - The impairments in reaching and the movements of compensation in rats with motor cortex...
20444958 - Randomized, double-blind, placebo-controlled trial of an iron-fortified food product in...
1314678 - Toxicity of silica-containing calcium phosphate glasses demonstrated in mice.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-20
Journal Detail:
Title:  Brain research     Volume:  1367     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Psychology, Clemson University, Clemson, SC 29634, USA. bking2@clemson.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
DK32089/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of maternal separation, early handling, and gonadal sex on regional metabolic capacity of th...
Next Document:  Visual mental imagery: what the head's eye tells the mind's eye.