Document Detail


Olfaction shapes host-parasite interactions in parasitic nematodes.
MedLine Citation:
PMID:  22851767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many parasitic nematodes actively seek out hosts in which to complete their lifecycles. Olfaction is thought to play an important role in the host-seeking process, with parasites following a chemical trail toward host-associated odors. However, little is known about the olfactory cues that attract parasitic nematodes to hosts or the behavioral responses these cues elicit. Moreover, what little is known focuses on easily obtainable laboratory hosts rather than on natural or other ecologically relevant hosts. Here we investigate the olfactory responses of six diverse species of entomopathogenic nematodes (EPNs) to seven ecologically relevant potential invertebrate hosts, including one known natural host and other potential hosts collected from the environment. We show that EPNs respond differentially to the odor blends emitted by live potential hosts as well as to individual host-derived odorants. In addition, we show that EPNs use the universal host cue CO(2) as well as host-specific odorants for host location, but the relative importance of CO(2) versus host-specific odorants varies for different parasite-host combinations and for different host-seeking behaviors. We also identified host-derived odorants by gas chromatography-mass spectrometry and found that many of these odorants stimulate host-seeking behaviors in a species-specific manner. Taken together, our results demonstrate that parasitic nematodes have evolved specialized olfactory systems that likely contribute to appropriate host selection.
Authors:
Adler R Dillman; Manon L Guillermin; Joon Ha Lee; Brian Kim; Paul W Sternberg; Elissa A Hallem
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-31
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-29     Completed Date:  2012-12-11     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E2324-33     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetoin / pharmacology
Aldehydes / pharmacology
Animals
Behavior, Animal / drug effects,  physiology
Calcium Compounds / pharmacology
Carbon Dioxide / pharmacology
Chemotaxis / drug effects
Chlorobenzenes / pharmacology
Cresols / pharmacology
Gastropoda / parasitology*
Gryllidae / parasitology*
Host-Parasite Interactions / physiology*
Monoterpenes / pharmacology
Nematoda / pathogenicity,  physiology*
Nematode Infections / physiopathology*
Odors
Oxides / pharmacology
Smell / physiology*
Sodium Hydroxide / pharmacology
Virulence
Grant Support
ID/Acronym/Agency:
T32GM07616/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Aldehydes; 0/Calcium Compounds; 0/Chlorobenzenes; 0/Cresols; 0/Monoterpenes; 0/Oxides; 124-38-9/Carbon Dioxide; 1310-73-2/Sodium Hydroxide; 1MXY2UM8NV/4-cresol; 4YGF4PQP49/gamma-terpinene; 513-86-0/Acetoin; 8006-28-8/soda lime; 9DC2K31JJQ/n-hexanal; D149TYB5MK/4-dichlorobenzene
Comments/Corrections

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