Document Detail

Olfaction and anosmia in rhinosinusitis.
MedLine Citation:
PMID:  15056406     Owner:  NLM     Status:  MEDLINE    
Olfactory disorders can cause serious consequences from the inability to detect many olfactory warning signals (eg, smoke, spoiled food, and gas leaks) and can significantly impact nutritional status, eating satisfaction, and many other issues related to quality of life. More than 200,000 people a year seek treatment for impaired olfactory ability, and available evidence suggests this figure is a significant underestimate of those affected. Rhinitis and rhinosinusitis are the primary etiologies for olfactory loss or distortion among patients presenting to chemosensory clinics, and they are among the most common chronic medical conditions in the United States, affecting an estimated 33 million people. Both allergic and nonallergic rhinitis/rhinosinusitis can result in diminished, distorted, or absent olfactory ability. Current therapies are only partially or transiently effective in reversing olfactory loss. The underlying mechanisms by which rhinitis/rhinosinusitis impact olfactory ability are likely to be multifactorial and might include altered air flow and odor deposition, changes in mucus composition, and effects of inflammatory mediators on receptor cell differentiation, maturation, or function.
Pamela Dalton
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current allergy and asthma reports     Volume:  4     ISSN:  1529-7322     ISO Abbreviation:  Curr Allergy Asthma Rep     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-01     Completed Date:  2004-07-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101096440     Medline TA:  Curr Allergy Asthma Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-6     Citation Subset:  IM    
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104-3308, USA.
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MeSH Terms
Olfaction Disorders / physiopathology*
Rhinitis / physiopathology*
Signal Transduction
Sinusitis / physiopathology*
Smell / physiology*

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