Document Detail


Oleuropein Offers Cardioprotection in Rats with Acute Myocardial Infarction.
MedLine Citation:
PMID:  25119867     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Myocardial infarction causes a cascade of events, which leads to heart failure, debilitation and death. This study examined possible cardioprotective effect of oleuropein in rats with acute myocardial infarction. Male Sprague-Dawly rats were allocated to five groups: sham, myocardial infarction receiving vehicle, and three myocardial infarction receiving oleuropein at 10, 20, and 30 mg/kg/day for 7 days, and underwent sham operation or coronary ligation. Twenty-four hours later, animals underwent echocardiographic and hemodynamic studies, and infarct areas, serum concentrations of oxidative stress and inflammatory markers were determined. Myocardial infarction group receiving vehicle had significantly lower left ventricular developed and systolic pressures, rate of rise/decrease of left ventricular pressure, stroke volume, ejection fraction and cardiac output, and serum superoxide dismutase and glutathione reductase than those of sham group. Pretreatment with oleuropein prevented the reduction of these variables. Moreover, the group had a significantly higher serum malondialdehyde, interleukin-1β, TNF-α, creatin kinase-MB, and troponin I, lactate dehydrogenase, and infarct area than those of sham group. Pretreatment with oleuropein prevented the increase of these variables. The findings indicate that coronary ligation results in acute myocardial infarction characterized by impaired cardiac function, and oleuropein pretreatment prevented cardiac impairment partly by reducing oxidative stress and release of proinflammatory cytokines.
Authors:
Zeinab Janahmadi; Ali Akbar Nekooeian; Ali Reza Moaref; Masoomeh Emamghoreishi
Related Documents :
25043397 - Diagnostic value of supar in differentiating non-cardiac pleural effusions from cardiac...
15513657 - Swedish council on technology assessment in health care (sbu). chapter 8. sick leave du...
17765117 - Reperfusion strategies in acute st-segment elevation myocardial infarction: a comprehen...
25124067 - Living cardiac tissue slices: an organotypic pseudo two-dimensional model for cardiac b...
9351747 - A novel prognostic scoring system to predict late outcome after percutaneous balloon va...
2350327 - Antiarrhythmic and antinecrotic effects of yohimbine stereoisomers in rats during coron...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-13
Journal Detail:
Title:  Cardiovascular toxicology     Volume:  -     ISSN:  1559-0259     ISO Abbreviation:  Cardiovasc. Toxicol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135818     Medline TA:  Cardiovasc Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Relevance of the current discussion on prioritization for rheumatology.
Next Document:  High-density single nucleotide polymorphism (SNP) array mapping in Brassica oleracea: identification...