Document Detail

Olestra formulation and the gastrointestinal tract.
MedLine Citation:
PMID:  10529087     Owner:  NLM     Status:  MEDLINE    
Olestra is a mixture of compounds comprising sucrose esterified with 6-8 long-chain fatty acids. It is not hydrolyzed by pancreatic lipase and as a result is not absorbed from the small intestine. Olestra in general has physical properties similar to those of a triacylglycerol with the same fatty acid composition. Foods made with olestra are virtually identical in taste and texture to those made with typical triacylglycerols. Olestra consumption does not generate hydrolytic products in the small intestine and, therefore, does not generate some of the signals that alter motility in the gastrointestinal tract. A reduction in gastroesophageal reflux with olestra, in contrast to triacylglycerols, is consistent with a lack of effect on stomach emptying. Unlike triacylglycerols that are absorbed in the proximal small intestine, olestra is distributed throughout the small intestine during transit and passes into the colon. In the colon, olestra's effects depend on its physical properties. Liquid nondigestible lipids result in separation of oil from the fecal matrix. Olestra formulations made with specific fatty acid compositions, particularly those containing a solid sucrose polyester component including behenic acid, possess appropriate rheology to hinder separation of oil from the rest of the fecal matrix, thereby reducing gastrointestinal symptoms.
R J Jandacek; J J Kester; A J Papa; T J Wehmeier; P Y Lin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lipids     Volume:  34     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-11-22     Completed Date:  1999-11-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  771-83     Citation Subset:  IM    
Procter & Gamble Miami Valley Laboratories and Winton Hill Technical Center, Cincinnati, Ohio 45253-8707, USA.
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MeSH Terms
Dietary Fats, Unsaturated / pharmacology
Digestive System / drug effects*
Fat Substitutes / pharmacology
Fatty Acids / pharmacology*
Mouth / drug effects
Sucrose / analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fat Substitutes; 0/Fatty Acids; 121854-29-3/sucrose polyester; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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