| Oleic acid synthesized in the periventricular zone promotes axonogenesis in the striatum during brain development. | |
| | |
MedLine Citation:
|
PMID: 20626566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Our previous works showed that oleic acid synthesized in vitro by astrocytes in response to albumin behaves as a neurotrophic factor in neurons, up-regulating several proteins, such as the axonal growth marker growth-associated protein 43(GAP-43). Although the molecular mechanism of this process is fairly known, there is no evidence pinpointing the region/s in which oleic acid is synthesized. In this study, we show that the rate-limiting enzyme in oleic acid synthesis, stearoyl-CoA desaturase (SCD-1), is located in the periventricular zone of the brain of newborn rats, simultaneously to an increase in the amount of free oleic acid in the forebrain. In addition, the spatio-temporal presence of albumin - the signal that promotes oleic acid synthesis - and that of GAP-43 are correlated with that of SCD-1. Using organotypic slice cultures, we found that albumin up-regulates SCD-1 and stimulates the growth of GAP-43-positive axons in the striatum. The effect of albumin on GAP-43 was reduced when SCD-1 was silenced by siRNA. In conclusion, our results suggest that albumin up-regulates axonogenesis in the striatum by increasing the amount of the neurotrophic factor oleic acid synthesized by SCD-1 in the periventricular zone of the newborn brain. |
| | |
Authors:
|
Erica Polo-Hernández; Fernando De Castro; Alejandro G García-García; Arantxa Tabernero; José M Medina |
Related Documents
:
|
9277406 - Fatty acid regulation of fatty acid-binding protein expression in the small intestine. 12204426 - An enzymatic method for the measurement of glycated albumin in biological samples. 8010966 - Characterization of binding and structural properties of rat liver fatty-acid-binding p... 2628426 - Interaction of fatty acids with beta-lactoglobulin and albumin from ruminant milk. 18776736 - Ordered bulk degradation via autophagy. 3568936 - Role of bacterial toxins, bile acids, and free fatty acids in colonic water malabsorpti... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-03 |
Journal Detail:
|
Title: Journal of neurochemistry Volume: 114 ISSN: 1471-4159 ISO Abbreviation: J. Neurochem. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-24 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: England |
Other Details:
|
Languages: eng Pagination: 1756-66 Citation Subset: IM |
Copyright Information:
|
© 2010 The Authors. Journal Compilation © 2010 International Society for Neurochemistry. |
Affiliation:
|
Departamento de Bioquímica y Biología Molecular, Instituto de Neurociencias de Castilla y León, INCYL, Universidad de Salamanca, Salamanca, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Albumins
/
metabolism Animals Animals, Newborn Axons / physiology* Cerebral Ventricles / growth & development, metabolism*, ultrastructure Corpus Striatum / growth & development, metabolism*, ultrastructure GAP-43 Protein / biosynthesis Gene Expression Regulation, Developmental Oleic Acid / biosynthesis* RNA, Small Interfering / genetics Rats Rats, Wistar Stearoyl-CoA Desaturase / genetics, metabolism Tissue Culture Techniques |
| Chemical | |
Reg. No./Substance:
|
0/Albumins; 0/GAP-43 Protein; 0/RNA, Small Interfering; 112-80-1/Oleic Acid; EC 1.14.19.1/Stearoyl-CoA Desaturase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The histone acetyltransferase Elp3 plays in active role in the control of synaptic bouton expansion ...
Next Document: Corticotrophin-releasing factor gene transcription is directly activated after deprivation of glucoc...