| Oleic acid inhibits store-operated calcium entry in human colorectal adenocarcinoma cells. | |
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MedLine Citation:
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PMID: 21956128 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS: Much evidence indicates the association between dietary fat and colorectal cancer risk. However, most of the studies focus on polyunsaturated fatty acids, and little is known about the role of monounsaturated ones and their precise mechanism of action. Being store-operated Ca(2+) entry (SOCE) a Ca(2+) influx pathway involved in the control of multiple cellular and physiological processes including cell proliferation, we studied the effect of oleic acid in Ca(2+) signals of colorectal cancer cells, paying particular attention to SOCE. METHODS: Carbachol was used to induce SOCE in Fura 2-loaded HT29 cells. We tested a saturated fatty acid to compare the physiological relevance of our results. RESULTS: We show that oleic acid is a potent inhibitor of SOCE. By contrast, stearic acid failed to have a SOCE-inhibitory effect. The SOCE-inhibition induced by oleic acid was protein kinase C-independent and restored by albumin. We also demonstrated that oleic acid induced increases in [Ca(2+)](i). The novelty of our report is that little variability in the concentration could end in a large different physiological effect. CONCLUSIONS: In conclusion, we suggest a physiological pathway for the beneficial effect of oleic acid in colon carcinoma cells. |
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Authors:
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Celia Carrillo; M Del Mar Cavia; Sara R Alonso-Torre |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-29 |
Journal Detail:
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Title: European journal of nutrition Volume: - ISSN: 1436-6215 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888704 Medline TA: Eur J Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Área de Nutrición y Bromatología, Facultad de Ciencias, Universidad de Burgos, Pl. Misael Bañuelos s/n, 09001, Burgos, Spain, ccarrillo@ubu.es. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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