| Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells. | |
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MedLine Citation:
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PMID: 22825128 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The antitumor activity of oleanolic (OA) has attracted attention due to its marked antitumor effects and pharmacological safety. In the present study, the effects of the combination of OA and 5-fluorouracil (5-FU) on Panc-28 human pancreatic cells were studied. The results showed that combined use of OA and 5-FU synergistically potentiated cell death effects on Panc-28 cells, and the pro-apoptotic effects were also increased. Further study revealed that the combined treatment could enhance mitochondrial depolarization, lysosomal membrane permeabilization (LMP) and leakage of cathepin D, while the release of cytochrome C did not display significant changes. The expression of apoptosis related proteins was also affected in cells treated with the combination of OA and 5-FU, including activation of caspases-3 and the expression of Bcl-2/Bax, survivin and NF-κB. Our results provide evidence that combination of OA and 5-FU may serve as a novel strategy for the treatment of pancreatic cancer. |
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Authors:
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Jianteng Wei; Haizhou Liu; Ming Liu; Ning Wu; Jin Zhao; Lin Xiao; Lijun Han; Edward Chu; Xiukun Lin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-19 |
Journal Detail:
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Title: Oncology reports Volume: - ISSN: 1791-2431 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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