| Oleanolic acid inhibits hypertrophic scarring in the rabbit ear model. | |
| | |
MedLine Citation:
|
PMID: 21392079 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background. Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of collagen and excessive deposition of extracellular matrix. Although treatment with surgical excision or steroid hormones can modify the symptoms, numerous treatment-related complications have been described. Aim. To investigate the effects of oleanolic acid (OA), a naturally occurring triterpenoid, on hypertrophic scarring in a rabbit ear model. Methods. A rabbit ear model of hypertrophic scarring was used, with wounds produced with a biopsy punch. Oleanolic acid (2.5%, 5% and 10%) was applied once daily to the scars for 22 days. On postoperative day 28, the scars were excised, and the tissue used for histological examination and assays of the levels of collagens I and III, matrix metalloproteinase (MMP)-1 and transforming growth factor (TGF)-β(1) . The scar elevation index (SEI) was also determined. Results. Treatment with different concentrations of oleanolic acid (OA) for 22 days significantly inhibited hypertrophic scarring in rabbit ear tissue. Levels of TGF-β(1) , collagen I and collagen III were significantly decreased and levels of MMP-1 significantly increased in the scar tissue. SEI was also significantly reduced. Histological findings showed significant amelioration of the scar tissue. Conclusions. OA suppresses hypertrophic scarring in the rabbit ear model and may be an effective cure for human hypertrophic scarring. |
| | |
Authors:
|
Y-J Wei; X-Q Yan; L Ma; J-G Wu; H Zhang; L-P Qin |
Related Documents
:
|
12236679 - Lignin deposition and associated changes in anatomy, enzyme activity, gene expression, ... 16196139 - Hplc-ms degradation study of e10 sunset yellow fcf in a commercial beverage. 17695919 - Photoassisted degradation of azodyes over feoxh2x-3/fe0 in the presence of h2o2 at neut... 11460319 - Photocatalytic degradation of trans-cinnamic, dihydrocinnamic, trans-caffeic, and dihyd... 20215059 - Global metabolite profiling of agarose degradation by saccharophagus degradans 2-40. 9642189 - Enantioselective uptake and degradation of the chiral herbicide dichlorprop [(rs)-2-(2,... 11964009 - A racemization test in peptide synthesis using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-m... 57909 - Further studies on the possibility of differential demonstration of radicals of sulphur... 17236029 - Rutin and scopoletin content and micropropagation of fabiana imbricata. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-11 |
Journal Detail:
|
Title: Clinical and experimental dermatology Volume: - ISSN: 1365-2230 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© The Author(s). CED © 2011 British Association of Dermatologists. |
Affiliation:
|
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, China School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China Department of Anaesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, China School of Traditional Chinese Medicine, Capital Medical University, Beijing, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Current application of National Institute for Health and Clinical Excellence (NICE) guidance in the ...
Next Document: Association between effective dose of prednisolone, alone or in conjunction with other immunosuppres...