| Olean-27-carboxylic acid-type triterpenes with potent antibacterial activity from Aceriphyllum rossii. | |
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MedLine Citation:
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PMID: 19053363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aceriphyllum rossii Engler (Saxifragaceae) have been used as a nutritious food in Korea. We found that the methanol extract of the root portion of A. rossii potently inhibited the growth of Staphylococcus aureus , with a minimal inhibitory concentration (MIC) value of 8 microg/mL. Using mass spectrometry and nuclear magnetic resonance (NMR) studies, four active constituents were isolated and identified: aceriphyllic acid A, 3-oxoolean-12-en-27-oic acid, 3alpha-hydroxyolean-12-en-27-oic acid, and 3beta-hydroxyolean-12-en-27-oic acid. Aceriphyllic acid A and 3-oxoolean-12-en-27-oic acid showed a potent antibacterial activity against several strains of S. aureus , including methicillin-resistant S. aureus and quinolone-resistant S. aureus , with MIC values of 2-8 microg/mL, while 3alpha-hydroxyolean-12-en-27-oic acid and 3beta-hydroxyolean-12-en-27-oic acid exhibited a very weak activity, with MIC values of 128 microg/mL. The methyl ester derivative of aceriphyllic acid A lost its antibacterial activity. The time-kill study against S. aureus indicated that aceriphyllic acid A had rapid bactericidal activity. These results indicated that aceriphyllic acid A and 3-oxoolean-12-en-27-oic acid are the most active principles, and both the carboxylic group at C-27 and the hydroxyl group at C-24 in aceriphyllic acid A are critical for the rapid bactericidal activity. |
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Authors:
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Chang-Ji Zheng; Mi-Jin Sohn; Ki-Young Kim; Hyung-Eun Yu; Won-Gon Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 56 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-18 Completed Date: 2009-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 11752-6 Citation Subset: IM |
Affiliation:
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Functional Metabolites Research Center, Korea Research Institute of Bioscience and Biotechnology, Post Office Box 115, Yusong, Daejeon 305-806, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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chemistry,
pharmacology* Bacteria / drug effects* Carboxylic Acids / chemistry, pharmacology* Cell Line Humans Oleanolic Acid / chemistry, pharmacology* Plant Extracts / chemistry, pharmacology Saxifragaceae / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Carboxylic Acids; 0/Plant Extracts; 508-02-1/Oleanolic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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