Document Detail


Olea sublingual allergoid immunotherapy administered with two different treatment regimens.
MedLine Citation:
PMID:  20406589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sublingual immunotherapy (SLIT) with monomeric carbamylated allergoid administered in accordance with the standard regimen has proven to be effective and safe. Achieving clinical benefit, however, requires a lengthy period of time so it is not very suitable for short-lasting allergies. We thus performed this study to compare an administration protocol starting in the coseasonal period (with a 4-day build-up phase) with a precoseasonal scheme to verify if the former regimen provides the same benefit in a shorter period of time. The prospective, randomized, drug therapy-controlled study was conducted in 33 rhinitic patients monosensitized to Olea with or without asthma. Ten patients were assigned to the coseasonal therapy with 5000 allergic units (AU)/week for 6 weeks, 11 to the precoseasonal therapy with 3000 AU/week for 10 weeks, and 12 to drug therapy. They were treated from April or May to June 2008. A visual analog scale (VAS) was performed at baseline and after treatment to assess the well being of the patients. Drug consumption was evaluated by means of a monthly diary. There was greater VAS improvement in both the SLIT groups versus the controls, but it was statistically significant only in the coseasonal group (p < 0.01). Furthermore, there was a reduction in the rescue medication only in the coseasonal SLIT (p < 0.05 versus drug therapy). One mild adverse event was observed. The allergoid SLIT was shown to be effective and safe in Olea allergy in particular when a coseasonal regimen was used.
Authors:
Salvatore Leonardi; Antonio Arena; Marco E Bruno; Paola M Cannaò; Roberto W D'Anneo; Paolo Falagiani; Enrico Gammeri; Gianni Mistrello; Alessandra Nicolini; Luisa Ricciardi; Giuseppe Valenti; Rosaria Longo; Mario La Rosa
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Allergy and asthma proceedings : the official journal of regional and state allergy societies     Volume:  31     ISSN:  1539-6304     ISO Abbreviation:  Allergy Asthma Proc     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-09-14     Revised Date:  2011-08-12    
Medline Journal Info:
Nlm Unique ID:  9603640     Medline TA:  Allergy Asthma Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e25-9     Citation Subset:  IM    
Affiliation:
Department of Pneumology, University, Catania, Italy.
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MeSH Terms
Descriptor/Qualifier:
Administration, Sublingual
Adolescent
Adult
Antigens, Plant / administration & dosage*,  immunology
Asthma / complications,  immunology,  physiopathology,  therapy*
Child
Clinical Protocols
Desensitization, Immunologic*
Female
Humans
Male
Olea / immunology*
Prospective Studies
Rhinitis, Allergic, Seasonal / complications,  immunology,  physiopathology,  therapy*
Seasons
Chemical
Reg. No./Substance:
0/Antigens, Plant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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