Document Detail

Oldest-old healthy brain function. The genomic potential.
MedLine Citation:
PMID:  9341566     Owner:  NLM     Status:  MEDLINE    
There will be a remarkable increase in the number of people older than 85 years--the oldest-old--in the next 50 years. This age group is especially vulnerable to increasing disabilities, many of which are the result of the aging nervous system. Among these aging changes, the most devastating and likely to have the greatest impact on our society is the development of dementia. Since dementia is present in the majority of those who live to the current maximum of the human life span, this suggests that dementia is a normal aging event. Although the exact causes of this common cognitive failure in the oldest-old are not known, there is recent evidence from genetic studies of aging and Alzheimer disease to suggest that there are a number of susceptibility genes that may modify or delay the onset of late-life brain failure. These gene families form a natural target for devising strategies for significantly delaying the onset of late-life dementia.
J A Kaye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Archives of neurology     Volume:  54     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-19     Completed Date:  1997-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1217-21     Citation Subset:  AIM; IM    
Department of Neurology, Oregon Health Sciences University, Portland, USA.
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MeSH Terms
Aged, 80 and over / physiology*
Brain / physiology*
Reference Values
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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