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Older Type 2 Diabetic Males do not Exhibit Abnormal Pulmonary Oxygen Uptake and Muscle Oxygen Utilization Dynamics During Sub-maximal Cycling Exercise.
MedLine Citation:
PMID:  21178129     Owner:  NLM     Status:  Publisher    
There are reports of abnormal pulmonary oxygen uptake (VO(2)) and deoxygenated hemoglobin ([HHb]) kinetics in individuals with Type 2 diabetes (T2D) below 50 years of age with disease durations of <5 years. We examined the O2 and muscle [HHb] kinetics in 12 older T2D patients with extended disease durations (age: 65 ± 5 years; disease duration 9.3 ± 3.8 years) and 12 healthy age-matched control participants (CON; age: 62 ± 6 years). Maximal oxygen uptake (VO(2) max) was determined via a ramp incremental cycle test and VO(2) and [HHb] kinetics were determined during subsequent sub-maximal step exercise. The VO(2) max was significantly reduced (P<0.05) in individuals with T2D compared to CON (1.98 ± 0.43 vs. 2.72 ± 0.40 L⋅min(-1), respectively) but, surprisingly, VO(2) kinetics was not different in T2D compared with CON (phase II time constant: 43 ± 17 vs. 41 ± 12 s, respectively). The [HHb]/VO(2) was significantly higher in T2D compared to CON (235 ± 99 vs. 135 ± 33 AU⋅ L⋅min(-1); P<0.05). Despite a lower VO(2) max, VO(2) kinetics is not different in older T2D compared to healthy age-matched control participants. The elevated [HHb]/VO(2) in T2D individuals possibly indicates a compromised muscle blood flow that mandates a greater O(2) extraction during exercise. Longer disease duration may result in adaptations in the O(2) extraction capabilities of individuals with T2D thereby mitigating the expected age-related slowing of VO(2) kinetics.
Daryl Paul Wilkerson; David C Poole; Andrew M Jones; Jonathan Fulford; Dave M Mawson; Claire I Ball; Angela C Shore
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-22
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1University of Exeter.
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