| Old beagle dogs have lower faecal concentrations of some fermentation products and lower peripheral lymphocyte counts than young adult beagles. | |
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MedLine Citation:
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PMID: 22005424 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The effects of age on microbiota composition, gut fermentation end-product formation and peripheral lymphocyte numbers were compared between old and young adult Beagle dogs fed four kibble diets differing in yeast cell wall contents. The experiment had a double 4 × 4 Latin square design, one with four mature dogs (4 years old) and the other with four old dogs (10 years old), with four replicates (diets) per dog. In each period a 15 d adaptation period preceded a 5 d total collection of faeces for the digestibility trial. On day 21, fresh faecal samples were collected for the determination of bacterial enumeration, pH, biogenic amine and short-chain fatty acid. Flow cytometry was used for immunophenotypic evaluation. Dogs were fed four kibble diets with similar composition with 0, 0·15, 0·30 and 0·45 % of yeast cell wall (as-fed), respectively. Data were evaluated using general linear models of Statistical Analysis Systems statistical software (P < 0·05). No evidence of a difference in faecal bacteria counts between ages was found (total aerobes, total anaerobes, Bifidobacterium, Lactobacillus, Clostridium and Escherichia coli: P>0·15). Faecal concentrations of butyrate, histamine, agmatine and spermine were lower (P ≤ 0·05) and faecal pH was higher (P = 0·03) in older dogs than in mature adult dogs, suggesting an alteration in bacterial metabolic activity, or in the rate of intestinal absorption of these compounds. Concentrations of T-lymphocytes, T-cytotoxic lymphocytes and B-lymphocytes were also lower (P ≤ 0·01) in older dogs than in mature adult dogs. The study confirmed alterations in peripheral lymphocytes and revealed a reduced concentration of some fermentation end products in the colon of old dogs. |
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Authors:
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Márcia de Oliveira Sampaio Gomes; Mariana Casteleti Beraldo; Thaila Cristina Putarov; Márcio Antônio Brunetto; Leandro Zaine; Maria Beatriz Abreu Glória; Aulus Cavalieri Carciofi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of nutrition Volume: 106 Suppl 1 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: S187-90 Citation Subset: IM |
Affiliation:
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Veterinary Medicine and Surgery Department, College of Agrarian and Veterinarian Sciences (FCAV), São Paulo State University - UNESP, Via de Acesso Prof. Paulo Donato Castellane, s/n. Jaboticabal, SP 14.884-900, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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