Document Detail


Olanzapine serum concentrations in psychiatric patients given standard doses: the influence of comedication.
MedLine Citation:
PMID:  10051059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We recorded steady state serum concentrations of olanzapine in 56 psychiatric patients under routine conditions. Twenty-two patients (39%) underwent monotherapy; the rest received additional psychotropic drugs. Doses were given once daily in the evening, and serum olanzapine levels were measured 12 hours later. For the whole group, the concentration-to-dose ratio (C/D) varied 26-fold, with a median value of 4.8 (nmol/L)/(mg/24 hours), but 80% of the patients had C/D values within the range 2 to 10 (nmol/L)/(mg/24 hours). All but three patients received standard doses (5-20 mg/24 hours), of whom 80% had serum concentrations of olanzapine within the range 22 to 146 nmol/L. Patients comedicated with potential inhibitors of CYP2D6 and other drugs displayed a median C/D approximately 40% higher than the group undergoing monotherapy. Patients comedicated with carbamazepine had a median C/D 36% lower than that of the monotherapy group. Therefore, the serum concentration range (12-hour values) of 25 to 150 nmol/L can be expected for patients receiving a standard daily dose.
Authors:
O V Olesen; K Linnet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  21     ISSN:  0163-4356     ISO Abbreviation:  Ther Drug Monit     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-05-28     Completed Date:  1999-05-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-90     Citation Subset:  IM    
Affiliation:
Institute for Basic Psychiatric Research, Department of Biological Psychiatry, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Risskov, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antipsychotic Agents / blood*,  pharmacokinetics
Benzodiazepines
Cytochrome P-450 CYP2D6 / antagonists & inhibitors
Drug Interactions
Drug Monitoring*
Enzyme Inhibitors / pharmacology*
Female
Humans
Male
Middle Aged
Pirenzepine / analogs & derivatives*,  blood,  pharmacokinetics
Psychotic Disorders / blood*,  metabolism
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Enzyme Inhibitors; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 28797-61-7/Pirenzepine; EC 1.14.14.1/Cytochrome P-450 CYP2D6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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