| Olanzapine serum concentrations in psychiatric patients given standard doses: the influence of comedication. | |
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MedLine Citation:
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PMID: 10051059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We recorded steady state serum concentrations of olanzapine in 56 psychiatric patients under routine conditions. Twenty-two patients (39%) underwent monotherapy; the rest received additional psychotropic drugs. Doses were given once daily in the evening, and serum olanzapine levels were measured 12 hours later. For the whole group, the concentration-to-dose ratio (C/D) varied 26-fold, with a median value of 4.8 (nmol/L)/(mg/24 hours), but 80% of the patients had C/D values within the range 2 to 10 (nmol/L)/(mg/24 hours). All but three patients received standard doses (5-20 mg/24 hours), of whom 80% had serum concentrations of olanzapine within the range 22 to 146 nmol/L. Patients comedicated with potential inhibitors of CYP2D6 and other drugs displayed a median C/D approximately 40% higher than the group undergoing monotherapy. Patients comedicated with carbamazepine had a median C/D 36% lower than that of the monotherapy group. Therefore, the serum concentration range (12-hour values) of 25 to 150 nmol/L can be expected for patients receiving a standard daily dose. |
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Authors:
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O V Olesen; K Linnet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Therapeutic drug monitoring Volume: 21 ISSN: 0163-4356 ISO Abbreviation: Ther Drug Monit Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-05-28 Completed Date: 1999-05-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7909660 Medline TA: Ther Drug Monit Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 87-90 Citation Subset: IM |
Affiliation:
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Institute for Basic Psychiatric Research, Department of Biological Psychiatry, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Risskov, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antipsychotic Agents / blood*, pharmacokinetics Benzodiazepines Cytochrome P-450 CYP2D6 / antagonists & inhibitors Drug Interactions Drug Monitoring* Enzyme Inhibitors / pharmacology* Female Humans Male Middle Aged Pirenzepine / analogs & derivatives*, blood, pharmacokinetics Psychotic Disorders / blood*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Enzyme Inhibitors; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 28797-61-7/Pirenzepine; EC 1.14.14.1/Cytochrome P-450 CYP2D6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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