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Olanzapine long-acting post-injection syndrome: a case report and brief review.
MedLine Citation:
PMID:  23440537     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The introduction of long-acting injectable atypical antipsychotics has ensured adherence to treatment in patients with low awareness of the disorder, with an acceptable rate of side effects. In the case of long acting olanzapine injection in particular, has particular relevance the existence of a special side-effect called post-injection syndrome. This rare side effect consisting in the presence of symptoms of olanzapine overdose after intramuscular administration of medication has led to restrictions on the use of the drug and the need for patient observation for three hours after each injection. We report a case of postinjection syndrome, to our knowledge, the first in Spain since the commercialization of Zypadhera. As in most cases described in the literature have symptoms of overdosage of olanzapine (dysarthria, sedation, fatigue, etc.) that are selflimiting without any therapeutic measure and are accompanied by supratherapeutic plasma levels of olanzapine.
Authors:
Santiago F Duran-Sindreu; Eva Grasa-Bello; Illuminada Corripio-Collado; Rosa B Sauras-Quetcuti; Alejandro Keymer-Gausset; Alexandra Roldán-Bejarano; Anna Alonso-Solís; María Figueras-Vilalta; Enric Alvarez-Martínez
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Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Actas españolas de psiquiatría     Volume:  41     ISSN:  1578-2735     ISO Abbreviation:  Actas Esp Psiquiatr     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-02-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886502     Medline TA:  Actas Esp Psiquiatr     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  60-2     Citation Subset:  IM    
Affiliation:
Servicio de Psiquiatría del Hospital de la Santa Creu i Sant Pau Barcelona.
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