Document Detail

Olanzapine and food craving: a case control study.
MedLine Citation:
PMID:  23169487     Owner:  NLM     Status:  Publisher    
BACKGROUND: Antipsychotic-induced weight gain is a problematic side effect. The mechanism is still not fully understood. Carbohydrate (and possibly other food) cravings have been suggested in literature, but not been systematically investigated. OBJECTIVES: To investigate the hypothesis that food cravings, especially for carbohydrate, are responsible for olanzapine-induced weight gain. METHOD: A case control design was used to measure general and specific food cravings using Food Craving Inventory (White et al., 2002) in three groups: patients with a diagnosis of schizophrenia taking olanzapine (Number = 20) or typical antipsychotics (Number = 20) and in a healthy control group (Number = 20). RESULTS: No statistically significant differences were found between the three groups in the craving scores. There was a trend in the typical group to show more cravings than other groups. CONCLUSION: Our study failed to prove the hypothesis that carbohydrate craving is responsible for olanzapine-induced weight gain. This conclusion is limited by the small number of the subjects included. Copyright © 2012 John Wiley & Sons, Ltd.
Mohammed J Abbas; Peter F Liddle
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-21
Journal Detail:
Title:  Human psychopharmacology     Volume:  -     ISSN:  1099-1077     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Bradgate Mental Health Unit, Leicester, UK.
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