| Olanzapine excretion in human breast milk: estimation of infant exposure. | |
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MedLine Citation:
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PMID: 12366877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Newer antipsychotic drugs offer significant clinical advantages for the treatment of psychosis. In particular for the treatment of postpartum disorders newer agents may be suited due to their favourable side-effect profiles. Of concern is the passage of the drugs into breast milk and what potential risks this poses for an infant who is breastfed. The excretion of olanzapine into the breast milk of five lactating women with postpartum psychosis was examined in this study. Nine pairs of plasma and breast-milk samples were collected and the concentration of olanzapine determined by high-performance liquid chromatography. Single-point milk-to-plasma ratios were calculated and ranged from 0.2 to 0.84 with a mean of 0.46. The median relative infant dose was 1.6% (range 0-2.5%) of the weight-adjusted maternal dose. During the study period, there were no apparent ill effects on the infant as a consequence of exposure to these doses of olanzapine. As with other antipsychotic drugs this study demonstrates that olanzapine passes into breast milk. The long-term effects of exposure in infants exposed to olanzapine requires further investigation. |
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Authors:
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Simon Croke; Anne Buist; L Peter Hackett; Kenneth F Ilett; Trevor R Norman; Graham D Burrows |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) Volume: 5 ISSN: 1461-1457 ISO Abbreviation: Int. J. Neuropsychopharmacol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-10-07 Completed Date: 2003-11-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9815893 Medline TA: Int J Neuropsychopharmacol Country: England |
Other Details:
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Languages: eng Pagination: 243-7 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Melbourne, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia. simon.croke@armc.org.ua |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / blood, pharmacokinetics*, therapeutic use Benzodiazepines Depression, Postpartum / drug therapy, metabolism, psychology Female Humans Infant Infant, Newborn Milk, Human / metabolism* Pirenzepine / analogs & derivatives*, blood, pharmacokinetics*, therapeutic use Psychiatric Status Rating Scales |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 28797-61-7/Pirenzepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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