Document Detail

Olanzapine does not enhance cognition in non-agitated and non-psychotic patients with mild to moderate Alzheimer's dementia.
MedLine Citation:
PMID:  16250069     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This was an exploratory study of olanzapine as potential treatment for improvement in cognition in patients with Alzheimer's disease without prominent psychobehavioral symptoms. METHODS: Non-psychotic/non-agitated patients (n = 268) with Alzheimer's disease, who had baseline Mini-Mental State Examination (MMSE) scores of 14-26 were randomized to treatment with olanzapine (2.5 to 7.5 mg/d) or placebo for 26 weeks. The primary objectives were to determine if treatment with olanzapine improved cognition as indexed by the Alzheimer's disease Assessment Scale for Cognition (ADAS-Cog) and the Clinician's Interview-Based Impression of Change (CIBIC) after 26 weeks of therapy. RESULTS: Patients treated with olanzapine vs placebo experienced significant worsening ADAS-Cog scores at weeks 12 (p = 0.03) and 26 (p = 0.004). Changes in CIBIC scores were not significantly different between treatment groups at either assessment. A post hoc analysis revealed that olanzapine-treated patients with more cognitive impairment at baseline (MMSE scores of 14-18) (n = 35) experienced significantly greater deterioration in ADAS-Cog performance than patients in the placebo group (n = 24; p < 0.001); whereas in patients with less cognitive impairment (n = 78, baseline MMSE scores of 23-26) between-group ADAS-Cog changes were not significant. CONCLUSIONS: In this 26-week study non-psychotic/non-agitated patients with Alzheimer's disease treated with olanzapine experienced significant worsening of cognition as compared to placebo.
John Kennedy; Walter Deberdt; Alan Siegal; Joseph Micca; Elisabeth Degenhardt; Jonna Ahl; Adam Meyers; Christopher Kaiser; Robert W Baker
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of geriatric psychiatry     Volume:  20     ISSN:  0885-6230     ISO Abbreviation:  Int J Geriatr Psychiatry     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-22     Completed Date:  2006-06-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8710629     Medline TA:  Int J Geriatr Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1020-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 John Wiley & Sons, Ltd.
University of Alberta and Chinook Regional Health System, Alberta, Canada.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / drug therapy,  psychology*
Antipsychotic Agents / adverse effects,  therapeutic use*
Benzodiazepines / adverse effects,  therapeutic use
Cognition Disorders / drug therapy*,  etiology
Disease Progression
Double-Blind Method
Middle Aged
Neuropsychological Tests
Prospective Studies
Psychiatric Status Rating Scales
Psychomotor Agitation
Treatment Outcome
Reg. No./Substance:
0/Antipsychotic Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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