| Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis. | |
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MedLine Citation:
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PMID: 19000740 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1-methyl-4-phenylpyridinium ion (MPP(+)) has been shown to selectively inhibit mitochondrial function and induce a parkinsonism-like syndrome. MPP(+) stimulates the production of reactive oxygen species (ROS) and induces cell death in vitro. In this study, we investigated the protective effects of okadaic acid on MPP(+)-induced cell death in SH-SY5Y neuroblastoma cells. We found that MPP(+)-induced apoptosis and -ROS generation were blocked by okadaic acid. MPP(+)-mediated activation of AKT was also inhibited by okadaic acid. Taken together, these results demonstrate that okadaic acid protects against MPP(+)-induced apoptosis by blocking ROS stimulation and ROS-mediated signaling pathways in SH-SY5Y cells. These data indicated that okadaic acid could provide a therapeutic strategy for the treatment of neurodegenerative diseases including Parkinson's disease. |
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Authors:
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Kook-Hee Ahn; Young-Sun Kim; Seon-Ye Kim; Youngbuhm Huh; Chan Park; Joo-Won Jeong |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-05 |
Journal Detail:
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Title: Neuroscience letters Volume: 449 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-03-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 93-7 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-4-phenylpyridinium
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antagonists & inhibitors Apoptosis / drug effects*, physiology Cell Line, Tumor Cytoprotection / drug effects, physiology Enzyme Inhibitors / pharmacology Herbicides / antagonists & inhibitors Humans Nerve Degeneration / drug therapy*, metabolism, physiopathology Neuroblastoma Neurons / drug effects*, metabolism, pathology Neuroprotective Agents / pharmacology Okadaic Acid / pharmacology* Oxidative Stress / drug effects*, physiology Parkinson Disease / drug therapy*, metabolism, physiopathology Protein Phosphatase 2 / antagonists & inhibitors, metabolism Proto-Oncogene Proteins c-akt / drug effects, metabolism Reactive Oxygen Species / antagonists & inhibitors, metabolism Signal Transduction / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Herbicides; 0/Neuroprotective Agents; 0/Reactive Oxygen Species; 48134-75-4/1-Methyl-4-phenylpyridinium; 78111-17-8/Okadaic Acid; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 3.1.3.16/Protein Phosphatase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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