| Okadaic acid inhibits phosphatidylethanolamine biosynthesis in rat hepatocytes. | |
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MedLine Citation:
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PMID: 1311568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Okadaic acid, a specific inhibitor of protein phosphatase 1 and 2A, inhibited the synthesis of phosphatidylethanolamine via the CDPethanolamine pathway in isolated hepatocytes. Pulse-chase experiments and measurement of the enzyme activity demonstrated that the inhibition of phosphatidylethanolamine synthesis was not caused by an inhibition of CTP:phosphoethanolamine cytidylyltransferase, the putative regulatory enzyme. However, okadaic acid decreased the cellular diacylglycerol level to 30% of that in control cells. The data suggest that the availability of diacylglycerol limits phosphatidylethanolamine synthesis in okadaic acid-treated hepatocytes. |
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Authors:
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L B Tijburg; P S Vermeulen; M G Schmitz; L M van Golde |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 182 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-03-27 Completed Date: 1992-03-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1226-31 Citation Subset: IM |
Affiliation:
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Laboratory of Veterinary Biochemistry, Utrecht University, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Ethanolamine Ethanolamines / metabolism Ethers, Cyclic / pharmacology* Kinetics Liver / drug effects, metabolism* Male Okadaic Acid Phosphatidylethanolamines / biosynthesis* Phospholipids / biosynthesis*, isolation & purification Phosphoprotein Phosphatases / antagonists & inhibitors Protein Phosphatase 1 Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Ethanolamines; 0/Ethers, Cyclic; 0/Phosphatidylethanolamines; 0/Phospholipids; 141-43-5/Ethanolamine; 78111-17-8/Okadaic Acid; EC 3.1.3.16/Phosphoprotein Phosphatases; EC 3.1.3.16/Protein Phosphatase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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