Document Detail

Okadaic acid blocks PDGF-induced proliferation of AKR-2B fibroblasts at the transition from G1- to S-phase.
MedLine Citation:
PMID:  7507848     Owner:  NLM     Status:  MEDLINE    
Okadaic acid (OA) at 100 ng/ml completely inhibited platelet-derived growth factor (PDGF)-BB-induced DNA synthesis but had no effect on early signals, i.e., PDGF receptor autophosphorylation or stimulation of inositolphosphate turnover. A detailed analysis using synchronized cells showed that OA acts at the transition from G1-phase to S-phase. These observations were confirmed by flow cytometric DNA analysis of asynchronously grown cells. Here cells were specifically arrested in the G1-phase.
A Simm; T A Karenberg; V Hoppe; J Hoppe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental cell research     Volume:  210     ISSN:  0014-4827     ISO Abbreviation:  Exp. Cell Res.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-03-10     Completed Date:  1994-03-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0373226     Medline TA:  Exp Cell Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  160-5     Citation Subset:  IM    
Theodor-Boveri-Institut für Biowissenschaften (Biozentrum) der Universität, Physiologische Chemie II, Würzburg, Germany.
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MeSH Terms
Cell Cycle / drug effects*
Cell Division / drug effects,  physiology*
Cell Line
DNA / biosynthesis,  drug effects
Dose-Response Relationship, Drug
Ethers, Cyclic / pharmacology*
Fibroblasts / cytology,  drug effects,  metabolism
G1 Phase / drug effects
Inositol Phosphates / metabolism
Mice, Inbred AKR
Okadaic Acid
Platelet-Derived Growth Factor / pharmacology*
Protein Tyrosine Phosphatases / antagonists & inhibitors*
Recombinant Proteins / pharmacology
S Phase / drug effects
Signal Transduction / drug effects
Thymidine / metabolism
Tyrosine / analogs & derivatives,  analysis,  metabolism
Reg. No./Substance:
0/Ethers, Cyclic; 0/Inositol Phosphates; 0/Platelet-Derived Growth Factor; 0/Recombinant Proteins; 0/platelet-derived growth factor BB; 21820-51-9/Phosphotyrosine; 50-89-5/Thymidine; 55520-40-6/Tyrosine; 78111-17-8/Okadaic Acid; 9007-49-2/DNA; EC Tyrosine Phosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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