Document Detail

Oil-soluble contrast during hysterosalpingography in women with proven tubal patency.
MedLine Citation:
PMID:  12517654     Owner:  NLM     Status:  MEDLINE    
To determine if there are therapeutic advantages to oil-soluble contrast medium compared with water-soluble medium during hysterosalpingography.A randomized, controlled trial including 56 infertile patients undergoing hysterosalpingography was performed. After a hysterosalpingogram with water-soluble contrast demonstrated tubal patency, 30 patients were randomized to receive oil-soluble contrast medium (oil group) and 26 patients received no additional contrast medium (control group). The outcome was pregnancy and timing of pregnancy in relation to hysterosalpingography. There were 18 (64%) pregnancies in the oil group and 14 (56%) pregnancies in the control group. Mean time to achieve pregnancy was shorter in the oil group: 3.8 months in the oil group compared with 6.1 months in the control group (P =.06) There was a clinically meaningful improvement in pregnancy rates between the oil group and the control group at 1 month postprocedure (relative risk [RR] 2.1, 95% confidence interval [CI] 0.6, 7.2). However, at 12 months postprocedure, the advantage was diminished. (RR 1.3, CI 0.8, 2.1)Eighteen months after hysterosalpingography, contrast does not appear to influence cumulative pregnancy rates; however, the addition of oil-soluble contrast medium to water-soluble contrast medium may have the potential to reduce the time to conception.
Anne Z Steiner; William R Meyer; Richard L Clark; Katherine E Hartmann
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  101     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-08     Completed Date:  2003-01-28     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-13     Citation Subset:  AIM; IM    
Departments of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina 27599-7570, USA.
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MeSH Terms
Contrast Media / therapeutic use*
Diatrizoate Meglumine / therapeutic use*
Ethiodized Oil / therapeutic use*
Hysterosalpingography / methods*
Infertility, Female / drug therapy*
Middle Aged
Pregnancy Rate
Reg. No./Substance:
0/Contrast Media; 131-49-7/Diatrizoate Meglumine; 8008-53-5/Ethiodized Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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