| Oil composition of high fat diet affects differently metabolic inflammation in connection with endotoxin receptors in mice. | |
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MedLine Citation:
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PMID: 22094473 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Low-grade inflammation observed in obesity is a risk factor for cardiovascular disease. Recent studies revealed that this would be linked to gut-derived endotoxemia during fat digestion in high fat diets, but nothing is known about the effect of lipid composition. The study was designed to test the impact of oil composition of high fat diets on endotoxin metabolism and inflammation in mice. C57/Bl6 mice were fed for 8 weeks with chow or isocaloric isolipidic diets enriched with oils differing in fatty acid composition: milk fat, palm oil, rapeseed oil or sunflower oil. In vitro, adipocytes (3T3-L1) were stimulated or not with lipopolysaccharide (LPS, endotoxin) and incubated with different fatty acids. In mice, the palm group presented the highest level of IL-6 in plasma (P<0.01) together with the highest expression in adipose tissue of IL-1β and of LPS-sensing TLR4 and CD14 (P<0.05). The higher inflammation in palm group was correlated with a greater ratio of LPS-Binding Protein (LBP)/sCD14 in plasma (P<0.05). Rapeseed group resulted in higher sCD14 than palm group, associated with lower inflammation both in plasma and adipose tissue despite higher plasma endotoxemia. Taken together, our results reveal that the palm oil-based diet resulted in the most active transport of LPS toward tissues via high LBP and low sCD14 and the greatest inflammatory outcomes. In contrast, rapeseed-oil based diet seemed to result in an endotoxin metabolism driven towards less inflammatory pathways. This shows that dietary fat composition can contribute to modulate the onset of low-grade inflammation through the quality of endotoxin receptors. |
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Authors:
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Fabienne Laugerette; Jean-Pierre Furet; Cyrille Debard; Patricia Daira; Emmanuelle Loizon; Alain Geloen; Christophe O Soulage; Claire Simonet; Jennifer Lefils-Lacourtablaise; Nathalie Bernoud-Hubac; Jacques Bodennec; Noël Peretti; Hubert Vidal; Marie-Caroline Michalski |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-15 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: - ISSN: 1522-1555 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1INRA USC1235, INSERM U1060, INSA-Lyon, IMBL. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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