Document Detail

Ohtahara syndrome: with special reference to its developmental aspects for differentiating from early myoclonic encephalopathy.
MedLine Citation:
PMID:  16829045     Owner:  NLM     Status:  MEDLINE    
RESULTS: Etiologically, structural brain lesions are most probable in OS, and non-structural/metabolic disorders in EME. Clinically, tonic spasms are the main seizures in OS, while myoclonia and frequent partial motor seizures in EME. Another difference is noted in EEG findings: suppression-bursts (SB) are consistently observed in both waking and sleeping states in OS, but suppression-bursts become more apparent in sleep in EME. The course observation clarifies differences between both syndromes; SBs evolve to hypsarrhythmia around 3-4 months of age, and sometimes further to diffuse slow spike-waves in OS. In contrast, in EME suppression-bursts may persist up to late childhood after a transient evolution to hypsarryhtmia in the middle to late infancy. Transition between syndromes is also specific; OS evolves to West syndrome, and further to Lennox-Gastaut syndrome with age, but EME persists long without such evolution excepting a transient phase of West syndrome.
CONCLUSION: These clinicoelectrical characteristics and differential points strongly indicate the efficiency of the developmental study to delineate both syndromes.
Shunsuke Ohtahara; Yasuko Yamatogi
Related Documents :
24274975 - Autoimmune thyroiditis: centennial jubilee of a social disease and its comorbidity.
16617025 - The pathophysiological mechanisms of cognitive and behavioral disturbances in children ...
3293355 - The temporal lobe epilepsy syndrome elucidated through søren kierkegaard's authorship a...
16302875 - Idiopathic generalized epilepsies recognized by the international league against epilepsy.
10513365 - Correction of knee deformity in patients with ellis-van creveld syndrome.
2012075 - Absent neutrophil alkaline phosphatase in the eosinophilia myalgia syndrome associated ...
Publication Detail:
Type:  Journal Article; Review     Date:  2006-07-10
Journal Detail:
Title:  Epilepsy research     Volume:  70 Suppl 1     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-16     Completed Date:  2006-10-26     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  S58-67     Citation Subset:  IM    
Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age of Onset
Diagnosis, Differential
Epilepsies, Myoclonic* / diagnosis,  etiology,  therapy
Epilepsy, Generalized* / diagnosis,  etiology,  therapy
Infant, Newborn
Mental Disorders / etiology
Psychomotor Disorders / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Are early myoclonic encephalopathy (EME) and the Ohtahara syndrome (EIEE) independent of each other?
Next Document:  Acute infantile encephalopathy predominantly affecting the frontal lobes (AIEF): a novel clinical ca...