Document Detail

Ofuji's disease with unusual histological features.
MedLine Citation:
PMID:  8689777     Owner:  NLM     Status:  MEDLINE    
A 20-year-old lady presented with a 3-month history of an itchy eruption affecting her face and trunk. Erythematous annular plaques with follicular papules and pustules at the margins were present on her face consistent with Ofuji's disease. A perifollicular and perivascular eosinophil-rich infiltrate was seen histologically, with infiltration of the follicular epithelium by eosinophils and formation of eosinophilic microabscesses. An unusual feature was the presence of follicular mucinosis. Treatment with dapsone resulted in an improvement in the eruption after 2 weeks. Ofuji's eosinophilic pustular folliculitis is becoming increasingly frequently recognized, and may not be as rare as initial reports suggested. In 1965, Ise and Ofuji reported the case of a Japanese woman who had recurrent episodes of follicular pustules affecting her face and back accompanied by a peripheral eosinophilia. Following this, in 1970 Ofuji et al. reported three further cases and proposed the name eosinophilic pustular folliculitis. Although many of the early cases were in Japanese patients, reports of this disease affecting individuals from Europe and the United States have been increasing.
T Basarab; R R Jones
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  21     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-08-26     Completed Date:  1996-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  IM    
St John's Institute of Dermatology, St Thomas' Hospital, UK.
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MeSH Terms
Dapsone / therapeutic use
Eosinophilia / drug therapy,  pathology*
Folliculitis / drug therapy,  pathology*
Leprostatic Agents / therapeutic use
Skin Diseases, Vesiculobullous / drug therapy,  pathology*
Reg. No./Substance:
0/Leprostatic Agents; 80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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