Document Detail

Office-based evaluation of renal function in elderly patients receiving nonsteroidal anti-inflammatory drugs.
MedLine Citation:
PMID:  3046231     Owner:  NLM     Status:  MEDLINE    
Elderly patients with multiple diseases who are receiving diuretics are at risk for renal dysfunction from nonsteroidal anti-inflammatory drugs (NSAIDs). Fifty-two elderly patients (mean age = 72 years, range = 63-87 years) with degenerative joint disease and multiple concomitant illnesses were randomly selected to receive ibuprofen suspension (400 mg) or aspirin (650 mg) 4 times a day. Serum creatinine (Cr), blood urea nitrogen (BUN), weight, and blood pressure were measured at baseline and at weekly intervals for 6 weeks. There were no significant changes from baseline in any tests reflective of renal function, no significant differences between ibuprofen and aspirin, and no influence of concomitant diuretic therapy. Ibuprofen and aspirin administered in the doses examined for 6 weeks appear to have little effect on renal function as measured by serum Cr and BUN in a sample of elderly patients for whom these drugs are commonly employed. Concomitant diuretic therapy does not appear to increase the risk. While these drugs are contraindicated in patients with severe hemodynamic insult, they should not be withheld from elderly patients who require this therapy for analgesic/anti-inflammatory effects because of concern for renal impairment. Further prospective research should be undertaken to clarify levels of patient risk and to define appropriate monitoring in such patients.
D M Cummings; P Amadio; S Nettler; M Freedman
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of the American Board of Family Practice / American Board of Family Practice     Volume:  1     ISSN:  0893-8652     ISO Abbreviation:  J Am Board Fam Pract     Publication Date:    1988 Apr-Jun
Date Detail:
Created Date:  1988-10-06     Completed Date:  1988-10-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8807505     Medline TA:  J Am Board Fam Pract     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Department of Pharmacy, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
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MeSH Terms
Aspirin / toxicity*
Clinical Trials as Topic
Diuretics / therapeutic use
Ibuprofen / toxicity*
Joint Diseases / drug therapy*
Kidney / drug effects*
Kidney Function Tests
Middle Aged
Prospective Studies
Random Allocation
Risk Factors
Grant Support
2D15PE13169-05/PE/BHP HRSA HHS
Reg. No./Substance:
0/Diuretics; 15687-27-1/Ibuprofen; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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