Document Detail

Offering excess oocyte aspiration and vitrification to patients undergoing stimulated artificial insemination cycles can reduce the multiple pregnancy risk and accumulate oocytes for later use.
MedLine Citation:
PMID:  20172866     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The prevention of multiple pregnancies remains a major challenge in patients treated with ovarian stimulation prior to intrauterine insemination (IUI). The pilot study presented here investigates whether multiple pregnancies can be minimized by a microscopically confirmed aspiration of oocytes from supernumerary follicles immediately before intrauterine insemination and evaluates the benefit of concomitant excess oocyte cryopreservation for future use. METHODS: Thirty-four aspirations of supernumerary follicles were performed immediately prior to IUI in 31 patients undergoing ovarian stimulation. sIUI was only performed if cumulus-oocyte complexes were microscopically observed in the aspirated follicular fluid. All collected mature excess oocytes were cryopreserved using the vitrification technique. RESULTS: Only four sIUI procedures had to be cancelled due to failed oocyte retrieval or premature ovulation. IUI treatment resulted in a clinical pregnancy rate of 23.5% per cycle. All were singleton pregnancies. A total of 111 oocytes were cryopreserved. Patients with polycystic ovary syndrome (PCOS) had an average of 6.07 oocytes vitrified, whereas patients without PCOS had 1.3 oocytes vitrified per cycle. CONCLUSION: Microscopically confirmed collection of excess oocytes prior to stimulated IUI reduced cancellation rates, further reduced the risk for multiple pregnancy and may lead to future additional pregnancies because, based on current information, approximately 5% of the vitrified oocytes could potentially establish a pregnancy.
D Stoop; L Van Landuyt; R Paquay; H Fatemi; C Blockeel; M De Vos; M Camus; E Van den Abbeel; P Devroey
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Publication Detail:
Type:  Journal Article     Date:  2010-02-19
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  25     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-29     Revised Date:  2010-10-22    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1213-8     Citation Subset:  IM    
Centre for Reproductive Medicine, University Hospital, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
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MeSH Terms
Age Factors
Cryopreservation / methods*
Infertility / therapy
Insemination, Artificial*
Oocyte Retrieval
Oocytes / cytology*
Ovarian Follicle / cytology,  growth & development
Ovulation Induction
Pilot Projects
Polycystic Ovary Syndrome / therapy
Pregnancy, Multiple*
Risk Factors
Treatment Outcome
Comment In:
Hum Reprod. 2010 Nov;25(11):2931; author reply 2931   [PMID:  20858695 ]

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