| Off-pump versus on-pump coronary artery surgery. | |
| | |
MedLine Citation:
|
PMID: 17379979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this preliminary, prospective, randomized study was to compare rotation thromboelastography (roTEG) results and D-dimer levels in off-pump versus on-pump coronary surgery in order to identify the activation of fibrinolysis. Twenty patients scheduled for coronary bypass grafting were assessed (off-pump group A, n = 10; on-pump group B, n = 10). Blood samples for roTEG examination were taken preoperatively (t0), 15 minutes after sternotomy (t1), on the completion of peripheral bypass anastomoses (t2), and at the end of procedures (t3). The time points for D-dimer levels analyses were before operation, at the end of procedures, and 24 hours later. A certain degree of roTEG signs of fibrinolysis was noticed at time t2 in both groups and in group B these marks were quite widely, but not significantly expressed (P for intergroup differences for Lysis on Set Time at 60 and 150 minutes were P = 0.190 and P = 0.122, respectively), borderline differences were found for Maximum Clot Firmness (P = 0.082) with a lower mean value for group B (arithmetic means [95% confidence intervals]--57.7 [54.2; 61.2] mm). Completely expressed roTEG signs of hyperfibrinolysis were observed in 2 patients from group B. In group B also the highest geometric means of D-dimers (1326.0 [943.5; 1863.6] ng mL(-1)) and thus a dramatic intergroup difference (P < 0.001) were observed at the end of surgery; 24 hours later the significantly elevated D-dimer levels in both groups (A: 1070.0 [723.5; 1582.6] versus B: 1093.3 [732.0; 1632.9] ng mL(-1)) were equalized (P = 0.932). Our roTEG results display a slightly greater, but fairly subtle activation of fibrinolysis during the course of cardiopulmonary bypass, compared to off-pump cardiac surgery. |
| | |
Authors:
|
Martin Jares; Tomas Vanek; Frantisek Bednar; Marek Maly; Jana Snircova; Zbynek Straka |
Related Documents
:
|
3720779 - The role of psychologic stress in the genesis of lethal arrhythmias in patients with co... 19923019 - Revelation of changing axis deviation at the end of atrial fibrillation without acute m... 7247909 - Unfavorable effects of ventricular pacing on myocardial energetics. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International heart journal Volume: 48 ISSN: 1349-2365 ISO Abbreviation: - Publication Date: 2007 Jan |
Date Detail:
|
Created Date: 2007-03-23 Completed Date: 2007-09-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101244240 Medline TA: Int Heart J Country: Japan |
Other Details:
|
Languages: eng Pagination: 57-67 Citation Subset: IM |
Affiliation:
|
Department of Cardiac Surgery, Third Faculty of Medicine, Charles University in Prague, Kralovske Vinohrady University Hospital, Prague, Czech Republic. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cardiopulmonary Bypass / methods* Coronary Artery Bypass, Off-Pump / methods* Female Fibrin Fibrinogen Degradation Products / metabolism Fibrinolysis / physiology* Follow-Up Studies Humans Male Middle Aged Monitoring, Intraoperative Myocardial Infarction / blood*, surgery* Prospective Studies Thrombelastography / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The relationship between acute phase serum amyloid A (SAA) protein concentrations and left ventricul...
Next Document: Comparison of the correlation of rebreathing method and echocardiography in heart failure patients w...