| Off-pump versus on-pump coronary artery bypass grafting: oxidative stress and renal function. | |
| | |
MedLine Citation:
|
PMID: 11675176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Oxidative stress and renal dysfunction occur in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass (on-pump CABG). Whether the same adverse effects also occur during off-pump CABG is the question in this study. METHODS: Forty patients, 27 men and 13 women, undergoing elective CABG were included; 20 patients underwent on-pump CABG and 20 patients underwent off-pump CABG. Renal and ischemia/reperfusion injury parameters were studied, as well as malondialdehyde as a parameter for oxidative stress. RESULTS: The renal function measured as the mean urinary creatinine excretion decreased significantly during surgery for the on-pump CABG group from 7.62+/-4.74 before surgery to 3.07+/-1.49 mmol/l after surgery, whereas no changes occurred in the off-pump CABG group. The mean urinary concentrations of hypoxanthine, xanthine and malondialdehyde expressed as creatinine ratios for the on-pump group increased significantly from 1.92+/-1.36, 6.06+/-3.62 and 0.21+/-0.07 before surgery to 11.88+/-5.77, 13.11+/-6.61 and 0.57+/-0.31 mmol/mol creatinine, respectively at arrival to the intensive care unit (ICU). During the next time-points, the purines and malondialdehyde decreased to 9.21+/-7.46, 7.55+/-3.95 and 0.32+/-0.13 mmol/mol creatinine, respectively after a 20 h stay at the ICU. For the off-pump CABG group, the mean ratios also increased significantly from 1.71+/-1.38, 2.01+/-0.96 and 0.16+/-0.10 before surgery to 4.73+/-3.19, 5.15+/-3.74 and 0.23+/-0.17 mmol/mol creatinine, respectively at arrival to the ICU. During the next time-points, the ratios of xanthine and malondialdehyde decreased to 3.80+/-2.92 and 0.24+/-0.13 mmol/mol creatinine, respectively. The ratio for hypoxanthine reached the highest ratio (6.97+/-5.67 mmol/mol creatinine) after a 9 h stay at the ICU, after which the ratio decreased to 5.98+/-5.56 mmol/mol creatinine after a 20 h stay at the ICU. However, all ratios from the on- and off-pump CABG patients still remained elevated compared with preoperative ratios. In addition, all ratios for the on-pump CABG group were elevated significantly at all time-points for xanthine, at time-points T2 and T4 for hypoxanthine and at time-point T2 for malondialdehyde as compared with the off-pump CABG group. CONCLUSIONS: Only mild signs of oxidative stress and no renal dysfunction were found during and after off-pump CABG compared with on-pump CABG. |
| | |
Authors:
|
W B Gerritsen; W J van Boven; A H Driessen; F J Haas; L P Aarts |
Related Documents
:
|
12826156 - Study of the activity of glutathione-peroxidase, glutathione-transferase, and glutathio... 12665476 - Induction of lox-1 and inos expressions by ischemia-reperfusion of rat kidney and the o... 19147816 - Adoptive transfer of syngeneic bone marrow-derived cells in mice with obesity-induced d... 7570946 - Simultaneous evaluation of nitric oxide synthesis and tissue oxygenation in rat liver a... 6744906 - Renal hypoxia and lactate metabolism in hemorrhagic shock in dogs. 9514546 - The effects of liver transplantation and cyclosporine on bile formation and lipid compo... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Volume: 20 ISSN: 1010-7940 ISO Abbreviation: Eur J Cardiothorac Surg Publication Date: 2001 Nov |
Date Detail:
|
Created Date: 2001-10-24 Completed Date: 2002-01-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8804069 Medline TA: Eur J Cardiothorac Surg Country: England |
Other Details:
|
Languages: eng Pagination: 923-9 Citation Subset: IM |
Affiliation:
|
Department of Clinical Chemistry, Sint Antonius Hospital, Nieuwegein, The Netherlands. w.gerritsen@kcl-azn.demon.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cardiopulmonary Bypass* Coronary Artery Bypass / methods* Creatinine / urine Female Humans Hypoxanthine / urine Kidney / physiology* Kidney Diseases / etiology Male Malondialdehyde / urine Middle Aged Oxidative Stress / physiology* Reperfusion Injury Uric Acid / urine Xanthine / urine |
| Chemical | |
Reg. No./Substance:
|
542-78-9/Malondialdehyde; 60-27-5/Creatinine; 68-94-0/Hypoxanthine; 69-89-6/Xanthine; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Feasibility of the utilisation of the right internal thoracic artery in the transverse sinus in off ...
Next Document: Preoperative prediction of prolonged mechanical ventilation following coronary artery bypass graftin...