| Off-pump mitral valve repair using the Coapsys device: a pilot study in a pacing-induced mitral regurgitation model. | |
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MedLine Citation:
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PMID: 14759460 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to evaluate the ability of the Myocor Coapsys device to restore leaflet apposition and valve competency off-pump in a canine model of functional mitral regurgitation (MR). DESCRIPTION: The Coapsys device was surgically implanted in 10 dogs after MR induction by rapid ventricular pacing. The Coapsys consists of anterior and posterior epicardial pads connected by a subvalvular chord. The annular head of the posterior pad was positioned at the annular level to draw the posterior leaflet and annulus toward the anterior leaflet. Final device size was selected when MR was minimized or eliminated as assessed by color flow Doppler echocardiography. EVALUATION: All implants were placed off-pump without atriotomy, and mean MR grade was reduced from 2.9 +/- 0.7 to 0.6 +/- 0.7 (p < 0.001) acutely. No hemodynamic compromise was noted. CONCLUSIONS: The Coapsys device consistently and significantly reduced or eliminated functional MR acutely. Further study will be required to assess the chronic stability of the repair in this animal model. |
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Authors:
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Kiyotaka Fukamachi; Masahiro Inoue; Zoran B Popović; Kazuyoshi Doi; Soren Schenk; Hassan Nemeh; Yoshio Ootaki; Michael W Kopcak; Raymond Dessoffy; James D Thomas; Richard W Bianco; James M Berry; Patrick M McCarthy |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 77 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-04 Completed Date: 2004-03-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: United States |
Other Details:
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Languages: eng Pagination: 688-92; discussion 692-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Biomedical Engineering, Lerner Research Institute, Cleveland, Ohio, USA. fukamach@bme.ri.ccf.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiac Pacing, Artificial* Cardiopulmonary Bypass* Coated Materials, Biocompatible Disease Models, Animal* Dogs Echocardiography, Doppler, Color Feasibility Studies Heart Failure / surgery, ultrasonography Heart Ventricles / surgery, ultrasonography Hemodynamics Mitral Valve / surgery*, ultrasonography Mitral Valve Insufficiency / surgery*, ultrasonography Polyesters Polytetrafluoroethylene Prostheses and Implants* |
| Chemical | |
Reg. No./Substance:
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0/Coated Materials, Biocompatible; 0/Polyesters; 9002-84-0/Polytetrafluoroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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