Document Detail

Off-pump Coronary Artery Bypass Surgery Induces Prolonged Alterations to Host Neutrophil Physiology.
MedLine Citation:
PMID:  23324884     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT: Persistent alteration to host polymorphonuclear cell (PMN) physiology has been demonstrated after cardiac surgery performed with cardiopulmonary bypass (CPB). However, to date, PMN physiology and function beyond the first 24 h have not been investigated after cardiac surgery performed without CPB (off-pump coronary artery bypass grafting [OPCAB]). Blood samples of 15 patients were collected preoperatively and on days 1, 3, and 5 after OPCAB. Expression of CD11b, CD18, CBRM1/5, and CD62L were assessed by flow cytometry under resting conditions and after stimulation with formyl methionyl-leucyl-phenylalanine (fMLF), and respiratory burst activity was also measured. Under resting conditions, PMN CD11b, CBRM1/5, and CD62L expressions were minimally altered by surgery. Compared with the response of preoperative PMNs, PMNs assayed on days 3 and 5 after OPCAB demonstrated a significantly blunted increase in the expression of CD11b and CBRM1/5 after fMLF, significantly diminished shedding of CD62L in response to platelet-activating factor and fMLF, and diminished superoxide production after stimulation on day 3. The alteration of PMN function after OPCAB implies that cardiac surgical trauma without CPB directly modulates host PMN physiology.
J James B Edelman; Yoke Lin Fung; Gabrielle J Pennings; Caroline J Reddel; Paul G Bannon; Matthew S Bayfield; Leonard Kritharides; John F Fraser; Michael P Vallely
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  39     ISSN:  1540-0514     ISO Abbreviation:  Shock     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
*The Baird Institute, Cardiothoracic Surgical Unit, Royal Prince Alfred Hospital, The University of Sydney, Sydney; and †ANZAC Research Institute, The University of Sydney, Concord Repatriation and General Hospital, Concord, New South Wales; and ‡Critical Care Research Group, University of Queensland & The Prince Charles Hospital, Brisbane, Queensland, Australia.
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