Document Detail


Off-line memory consolidation impairments in multiple sclerosis patients receiving high-dose corticosteroid treatment mirror consolidation impairments in depression.
MedLine Citation:
PMID:  20223599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sleep supports the consolidation of procedural memory, however patients with major depression show impaired motor memory performance after a night of sleep. It was hypothesized that this impairment is related to hypothalamic-pituitary-adrenal (HPA) axis dysfunction. We tested if high-dose administration of corticosteroids impairs off-line motor memory consolidation in patients with multiple sclerosis (MS).
METHODS: Nine patients with MS receiving high-dose corticosteroid therapy (methylprednisolone) and nine MS patients receiving alternative therapy (mitoxantrone) were assessed using a sequential finger tapping task before and after a night with polysomnography. In addition, nine patients with major depression (MD) receiving antidepressants and nine healthy controls were assessed.
RESULTS: Although the four groups did not differ in practice-dependent learning, healthy subjects and MS patients receiving mitoxantrone showed markedly overnight-improvements in tapping performance of 17% and 24% while MS patients receiving high-dose corticosteroid therapy and depressed patients showed -9% and -10% overnight decrease. MS patients with and without corticosteroid therapy did not differ in their amount of REM sleep, nor did MD patients and healthy controls. In addition, we did not find any correlation between REM sleep and memory consolidation.
CONCLUSION: Our results show that a strong intervention into the HPA system like in MS high-dose corticosteroid therapy impairs off-line motor memory consolidation comparable to the impairments seen in depressed patients. We propose therefore that depression-related changes in plasma corticosteroid levels rather than in sleep per se underlie off-line memory consolidation impairments in MD.
Authors:
Martin Dresler; Lisa Genzel; Michael Kluge; Petra Schüssler; Frank Weber; Marcus Rosenhagen; Axel Steiger
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-11
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  35     ISSN:  1873-3360     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1194-202     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Max Planck Institute of Psychiatry, Munich, Germany. dresler@mpipsykl.mpg.de
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / administration & dosage,  adverse effects*
Adult
Aged
Depression / complications*,  physiopathology*
Dose-Response Relationship, Drug
Female
Humans
Male
Memory / drug effects,  physiology
Memory Disorders / chemically induced,  etiology*,  physiopathology
Methylprednisolone / administration & dosage,  adverse effects
Middle Aged
Mitoxantrone / administration & dosage,  adverse effects
Multiple Sclerosis / drug therapy*,  physiopathology
Neuroprotective Agents / administration & dosage,  adverse effects
Psychomotor Performance / drug effects,  physiology
Sleep / drug effects,  physiology
Sleep Disorders / chemically induced,  etiology*,  physiopathology
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Neuroprotective Agents; 65271-80-9/Mitoxantrone; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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