| Off-line memory consolidation impairments in multiple sclerosis patients receiving high-dose corticosteroid treatment mirror consolidation impairments in depression. | |
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MedLine Citation:
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PMID: 20223599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sleep supports the consolidation of procedural memory, however patients with major depression show impaired motor memory performance after a night of sleep. It was hypothesized that this impairment is related to hypothalamic-pituitary-adrenal (HPA) axis dysfunction. We tested if high-dose administration of corticosteroids impairs off-line motor memory consolidation in patients with multiple sclerosis (MS). METHODS: Nine patients with MS receiving high-dose corticosteroid therapy (methylprednisolone) and nine MS patients receiving alternative therapy (mitoxantrone) were assessed using a sequential finger tapping task before and after a night with polysomnography. In addition, nine patients with major depression (MD) receiving antidepressants and nine healthy controls were assessed. RESULTS: Although the four groups did not differ in practice-dependent learning, healthy subjects and MS patients receiving mitoxantrone showed markedly overnight-improvements in tapping performance of 17% and 24% while MS patients receiving high-dose corticosteroid therapy and depressed patients showed -9% and -10% overnight decrease. MS patients with and without corticosteroid therapy did not differ in their amount of REM sleep, nor did MD patients and healthy controls. In addition, we did not find any correlation between REM sleep and memory consolidation. CONCLUSION: Our results show that a strong intervention into the HPA system like in MS high-dose corticosteroid therapy impairs off-line motor memory consolidation comparable to the impairments seen in depressed patients. We propose therefore that depression-related changes in plasma corticosteroid levels rather than in sleep per se underlie off-line memory consolidation impairments in MD. |
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Authors:
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Martin Dresler; Lisa Genzel; Michael Kluge; Petra Schüssler; Frank Weber; Marcus Rosenhagen; Axel Steiger |
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Publication Detail:
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Type: Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-11 |
Journal Detail:
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Title: Psychoneuroendocrinology Volume: 35 ISSN: 1873-3360 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: England |
Other Details:
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Languages: eng Pagination: 1194-202 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Max Planck Institute of Psychiatry, Munich, Germany. dresler@mpipsykl.mpg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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administration & dosage,
adverse effects* Adult Aged Depression / complications*, physiopathology* Dose-Response Relationship, Drug Female Humans Male Memory / drug effects, physiology Memory Disorders / chemically induced, etiology*, physiopathology Methylprednisolone / administration & dosage, adverse effects Middle Aged Mitoxantrone / administration & dosage, adverse effects Multiple Sclerosis / drug therapy*, physiopathology Neuroprotective Agents / administration & dosage, adverse effects Psychomotor Performance / drug effects, physiology Sleep / drug effects, physiology Sleep Disorders / chemically induced, etiology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Neuroprotective Agents; 65271-80-9/Mitoxantrone; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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