Document Detail


Off-label use of rituximab in systemic lupus erythematosus: a systematic review.
MedLine Citation:
PMID:  20155295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Considerable interest in the efficacy of rituximab (a monoclonal CD20 antibody) in patients with systemic lupus erythematosus (SLE) has been generated due to its unique mode of action, culminating in a series of randomized and open trials, and case reports. However, this use is off-license and two significant RCTs have reported negative findings, reopening the debate on clinical benefit. This review of the available data suggests that rituximab induces B-cell depletion in 95% of patients, and a significant reduction in disease activity is achieved with a relatively good safety profile in patients with SLE.
Authors:
Eleanor Murray; Martin Perry
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-02-13
Journal Detail:
Title:  Clinical rheumatology     Volume:  29     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  707-16     Citation Subset:  IM    
Affiliation:
Western Infirmary General, G-3/4, Glasgow, G11 6NT, UK. eleanormurray@doctors.org.uk
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / adverse effects,  pharmacology,  therapeutic use*
B-Lymphocytes / cytology,  drug effects,  immunology
Down-Regulation / drug effects
Humans
Lupus Erythematosus, Systemic / drug therapy*
Off-Label Use*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/rituximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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