| Off-axis photoacoustic microscopy. | |
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MedLine Citation:
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PMID: 20176531 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Photoacoustic microscopy (PAM) is a high-contrast, high-resolution imaging modality, used primarily for imaging hemoglobin and melanin. Important applications include mapping of the microvasculature and melanoma tumor margins. We demonstrate a novel PAM design that markedly simplifies the implementation by separating the optical illumination from the acoustic detection path. This modification enables the use of high-quality commercial optics and transducers, and may be readily adapted to commercial light microscopes. The designed PAM system is only sensitive to signals generated in the overlap of the illumination and detection solid angles, providing the additional benefit of quasi-dark-field detection. An off-axis PAM system with a lateral resolution of 26 microm and a modest axial resolution of 410 microm has been assembled and characterized using tissue samples. The axial resolution is readily scaled down to tens of micrometers within the same design, by utilizing commercially available high-frequency acoustic transducers. |
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Authors:
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Ryan L Shelton; Brian E Applegate |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-02-18 |
Journal Detail:
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Title: IEEE transactions on bio-medical engineering Volume: 57 ISSN: 1558-2531 ISO Abbreviation: IEEE Trans Biomed Eng Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-11-05 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 1835-8 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA. shelton8r@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chickens Hair / chemistry Humans Meat / analysis Microscopy, Acoustic / methods* Models, Biological Transducers |
| Grant Support | |
ID/Acronym/Agency:
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R21 EB007729-02/EB/NIBIB NIH HHS; R21EB007729/EB/NIBIB NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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