Document Detail


Oestrogen and progestins differently prevent glutamate toxicity in cortical neurons depending on prior hormonal exposure via the induction of neural nitric oxide synthase.
MedLine Citation:
PMID:  19463685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sex steroids are important for brain function and protection. However, growing evidence suggests that these actions might depend on the timing of exposure to steroids. We have studied the effects of steroid administration on the survival of neural cells and we have partially characterized the possible mechanisms. The effect of a 24h pre-treatment with 17beta-estradiol or 17beta-estradiol plus progesterone or medroxyprogesterone acetate on the toxic action of l-glutamate was used to test the experimental hypothesis. Pre-exposure to either steroid combinations turned in enhanced cell survival. Instead, addition of sex steroids together with l-glutamate, in the absence of a pre-exposure had no protective effect. Pre-treatment with the steroid combinations resulted in increased neural NOS expression and activity and blockade of NOS abolished the cytoprotective effects of steroids. These results suggest that NOS induction might be involved in sex steroid-induced neuroprotection. Furthermore, these data supports the hypothesis that prolonged and continued exposure to oestrogen and progesterone, leading to changes in gene expression, is necessary to obtain neuroprotection induced by sex steroids.
Authors:
Paolo Mannella; Angel Matias Sanchez; Maria Silvia Giretti; Andrea Riccardo Genazzani; Tommaso Simoncini
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Publication Detail:
Type:  Journal Article     Date:  2009-03-17
Journal Detail:
Title:  Steroids     Volume:  74     ISSN:  1878-5867     ISO Abbreviation:  Steroids     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-09-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  650-6     Citation Subset:  IM    
Affiliation:
Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, 56100, Italy. p.mannella@obgyn.med.unipi.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Survival / drug effects
Cerebral Cortex / cytology*
Cytoprotection / drug effects
Enzyme Induction / drug effects
Estrogens / pharmacology*
Glutamic Acid / toxicity*
Medroxyprogesterone Acetate / pharmacology
Neurons / cytology,  drug effects*,  enzymology*,  metabolism
Nitric Oxide Synthase / biosynthesis*,  metabolism
Progestins / pharmacology*
Rats
Chemical
Reg. No./Substance:
0/Estrogens; 0/Progestins; 56-86-0/Glutamic Acid; 71-58-9/Medroxyprogesterone Acetate; EC 1.14.13.39/Nitric Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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