Document Detail


Oestrogen production by the goat mammary gland: transient aromatase activity during late pregnancy.
MedLine Citation:
PMID:  2338526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammary tissue from goats had significantly higher aromatase activity at 148-149 days of pregnancy than earlier in pregnancy or during lactation. Aromatase activity was determined by production of 3H2O from [1 beta-3H]androstenedione that was inhibited by 4-hydroxyandrostenedione. The time of maximum aromatization was during peak mammary output of oestradiol-17 beta described previously in vivo in the same species. Aromatase activity in the mouse mammary gland was low and no peak was observed in late pregnancy. It is concluded that the oestrogens produced by the mammary gland in the late-pregnant goat are formed by aromatization of androgens.
Authors:
M Peaker; E Taylor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  125     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-06-18     Completed Date:  1990-06-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  R1-3     Citation Subset:  IM    
Affiliation:
Hannah Research Institute, Ayr.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aromatase / metabolism*
Estrogens / biosynthesis*
Female
Goats / metabolism*
Lactation / metabolism
Mammary Glands, Animal / enzymology,  metabolism*
Mice
Pregnancy
Pregnancy, Animal / metabolism*
Chemical
Reg. No./Substance:
0/Estrogens; EC 1.14.14.1/Aromatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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