Document Detail

Oestrogen-induced myometrial quiescence in the post-partum rat is not mediated by adrenaline or by alpha- or beta-adrenoceptor activation.
MedLine Citation:
PMID:  6251149     Owner:  NLM     Status:  MEDLINE    
Ovariectomized post-partum rats exhibit in vivo continuous stable myometrial activity with a frequency of 45--50 pressure cycles per h, and a mean maximum amplitude of 45--50 mmHg for many days. Oestradiol benzoate (5 micrograms) reduced the frequency of intra-uterine pressure cycles to 5 cycles per h by 20 h after treatment. The decrease in frequency was due to increased periods of uterine quiescence. Pretreatment with reserpine caused significant reductions in the concentration of uterine adrenaline and noradrenaline as measured by a fluorometric assay but had no effect on the extent or time-course of oestrogen-induced myometrial quiescence. Neither intravenous infusion of the adrenergic beta-blocker, propranolol, altered the extent or the time-course of the reduction of intra-uterine pressure cycles after oestrogen treatment. These results suggest that the mechanism by which oestrogen induces myometrial quiescence does not involve adrenaline mediation or alpha- or beta-adrenoceptor activation.
S J Downing; D G Porter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  85     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-11-25     Completed Date:  1980-11-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  405-13     Citation Subset:  IM    
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MeSH Terms
Epinephrine / metabolism*
Estradiol / pharmacology*
Myometrium / drug effects
Norepinephrine / metabolism
Orciprenaline / pharmacology
Phentolamine / pharmacology
Postpartum Period
Propranolol / pharmacology
Receptors, Adrenergic / drug effects*
Receptors, Adrenergic, alpha / drug effects*
Receptors, Adrenergic, beta / drug effects*
Reserpine / pharmacology
Uterine Contraction / drug effects*
Uterus / metabolism
Reg. No./Substance:
0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 50-28-2/Estradiol; 50-55-5/Reserpine; 50-60-2/Phentolamine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 525-66-6/Propranolol; 586-06-1/Orciprenaline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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